Arhgef15 MGI Mouse Gene Detail - MGI:3045246 - Rho guanine nucleotide exchange factor 15

Symbol

Arhgef15
Name

Rho guanine nucleotide exchange factor 15
Synonyms

D530030K12Rik

Feature Type

protein coding gene
IDs

MGI:3045246
NCBI Gene: 442801
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:68833981-68848306 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.21 cM
Mapping Data

1 experiment

SNPs within 2kb

453 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3045246	protein coding gene	Chr11:68819726-68848306 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018509	protein coding gene	Chr11:69332190-69347844 (-)
A/J	MGP_AJ_G0018478	protein coding gene	Chr11:66732274-66747038 (-)
AKR/J	MGP_AKRJ_G0018447	protein coding gene	Chr11:68727736-68742030 (-)
BALB/cJ	MGP_BALBcJ_G0018449	protein coding gene	Chr11:67041101-67065181 (-)
C3H/HeJ	MGP_C3HHeJ_G0018262	protein coding gene	Chr11:68745519-68761328 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018901	protein coding gene	Chr11:71438659-71456990 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016545	protein coding gene	Chr11:63668770-63683703 (-)
CAST/EiJ	MGP_CASTEiJ_G0017818	protein coding gene	Chr11:68982652-68997018 (-)
CBA/J	MGP_CBAJ_G0018236	protein coding gene	Chr11:74632083-74646329 (-)
DBA/2J	MGP_DBA2J_G0018345	protein coding gene	Chr11:66327505-66342880 (-)
FVB/NJ	MGP_FVBNJ_G0018335	protein coding gene	Chr11:65948947-65963793 (-)
LP/J	MGP_LPJ_G0018416	protein coding gene	Chr11:69914534-69928802 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018358	protein coding gene	Chr11:75288173-75302913 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018942	protein coding gene	Chr11:68967975-68982252 (-)
PWK/PhJ	MGP_PWKPhJ_G0017593	protein coding gene	Chr11:66957627-66972235 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017381	protein coding gene	Chr11:68791992-68807394 (-)
WSB/EiJ	MGP_WSBEiJ_G0017871	protein coding gene	Chr11:68611013-68627886 (-)

Human Ortholog

ARHGEF15, Rho guanine nucleotide exchange factor 15

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGEF15, Rho guanine nucleotide exchange factor 15
Synonyms

ARGEF15, E5, Ephexin5, Vsm-RhoGEF
Links

HGNC:15590

NCBI Gene ID: 22899

neXtProt AC: NX_O94989

UniProt: O94989
Chr Location

17p13.1; chr17:8310241-8322514 (+) GRCh38

MGI Vertebrate Homology

Arhgef15 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ARHGEF15
Gene Tree

Arhgef15

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Phenotype Summary

9 phenotypes from 4 alleles in 4 genetic backgrounds
1 images
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

2
Targeted

8
Genomic Mutations

1 involving Arhgef15
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock out allele exhibit increased excitatory synapse formation. Mice homozygous for a knock-out allele exhibit delayed radial growth, sparse vasculature and empty baselment membrane sleeves in the retina.

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All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

834
Tissues

40
cDNA Data

22
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN arhgef15b

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All Sequences

80
RefSeq

41
UniProt

2
CCDS

CCDS24873.1

Ensembl

ENSMUSG00000052921 (Evidence)
NCBI Gene

442801

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052921	Ensembl Gene Model \| MGI Sequence Detail	14326	C57BL/6J	± kb
transcript	ENSMUST00000065040	Ensembl \| MGI Sequence Detail	4123	Not Applicable
polypeptide	ENSMUSP00000067684	Ensembl \| MGI Sequence Detail	849	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004250 Rho guanine nucleotide exchange factor 15

(term hierarchy)
InterPro Domains

IPR000219 Dbl homology (DH) domain

IPR035899 Dbl homology (DH) domain superfamily

IPR047271 Ephexin-like

IPR047270 Ephexin-like, PH domain

IPR011993 PH-like domain superfamily

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All nucleic 22

cDNA 22

Microarray probesets 3

Summaries

All 46

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 18
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Arhgef15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108608	Chr11:68848271-68848311 (-)	15 bp
Tssr108607	Chr11:68847699-68847735 (-)	589 bp
Tssr108606	Chr11:68847021-68847055 (-)	1,268 bp
Tssr108605	Chr11:68838366-68838400 (-)	9,923 bp
Tssr108604	Chr11:68838199-68838238 (-)	10,087 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24