Cemip2 MGI Mouse Gene Detail - MGI:1890373 - cell migration inducing hyaluronidase 2

Symbol

Cemip2
Name

cell migration inducing hyaluronidase 2
Synonyms

3110012M15Rik, mKIAA1412, Tmem2

Feature Type

protein coding gene
IDs

MGI:1890373
NCBI Gene: 83921
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr19:21755706-21835724 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 15.54 cM
Mapping Data

2 experiments

SNPs within 2kb

3089 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890373	protein coding gene	Chr19:21755704-21835724 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024981	protein coding gene	Chr19:19848371-19929585 (+)
A/J	MGP_AJ_G0024958	protein coding gene	Chr19:18760680-18840332 (+)
AKR/J	MGP_AKRJ_G0024928	protein coding gene	Chr19:19467272-19548246 (+)
BALB/cJ	MGP_BALBcJ_G0024957	protein coding gene	Chr19:18766694-18846951 (+)
C3H/HeJ	MGP_C3HHeJ_G0024715	protein coding gene	Chr19:19421158-19502138 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025399	protein coding gene	Chr19:20507648-20592522 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022818	protein coding gene	Chr19:18972282-19050273 (+)
CAST/EiJ	MGP_CASTEiJ_G0024183	protein coding gene	Chr19:19124207-19204602 (+)
CBA/J	MGP_CBAJ_G0024693	protein coding gene	Chr19:21341055-21420446 (+)
DBA/2J	MGP_DBA2J_G0024825	protein coding gene	Chr19:18769134-18849502 (+)
FVB/NJ	MGP_FVBNJ_G0024786	protein coding gene	Chr19:18624892-18705296 (+)
LP/J	MGP_LPJ_G0024909	protein coding gene	Chr19:19806000-19888044 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024813	protein coding gene	Chr19:21472901-21558158 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025454	protein coding gene	Chr19:19420405-19504641 (+)
PWK/PhJ	MGP_PWKPhJ_G0023932	protein coding gene	Chr19:18322357-18407780 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023737	protein coding gene	Chr19:18701243-18785172 (+)
WSB/EiJ	MGP_WSBEiJ_G0024251	protein coding gene	Chr19:19500518-19584732 (+)

Human Ortholog

CEMIP2, cell migration inducing hyaluronidase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CEMIP2, cell migration inducing hyaluronidase 2
Synonyms

TMEM2
Links

HGNC:11869

NCBI Gene ID: 23670

neXtProt AC: NX_Q9UHN6

UniProt: Q9UHN6
Chr Location

9q21.13; chr9:71683366-71816690 (-) GRCh38

MGI Vertebrate Homology

Cemip2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CEMIP2
Gene Tree

Cemip2

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

71
Endonuclease-mediated

3
Gene trapped

64
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

94 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for loss of expression display accumulation and impaired degradation of hyaluronan.

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

907
Tissues

153
cDNA Data

160
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cemip2

ZFIN cemip2

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All Sequences

61
RefSeq

4
UniProt

3
CCDS

CCDS37934.1

Ensembl

ENSMUSG00000024754 (Evidence)
NCBI Gene

83921

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024754	Ensembl Gene Model \| MGI Sequence Detail	80019	C57BL/6J	± kb
transcript	ENSMUST00000025663	Ensembl \| MGI Sequence Detail	6602	Not Applicable
polypeptide	ENSMUSP00000025663	Ensembl \| MGI Sequence Detail	1383	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000030473 cell surface hyaluronidase CEMIP2

(term hierarchy)
EC

3.2.1.35
InterPro Domains

IPR039473 Cell surface hyaluronidase, PANDER-like domain

IPR019316 G8 domain

IPR052252 Hyaluronic acid metabolism regulator

IPR039477 ILEI/PANDER domain

IPR011050 Pectin lyase fold/virulence factor
GlyGen

Q5FWI3 11 sites, 14 N-linked glycans (11 sites)

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All nucleic 167

cDNA 160

Primer pair 3

Other 4

Microarray probesets 6

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MGI:1920320, MGI:6192064

Summaries

All 48

Developmental Gene Expression 13

Gene Ontology 6

Phenotypes 13
Earliest

J:68964 Scott DA, et al., Refining the DFNB7-DFNB11 deafness locus using intragenic polymorphisms in a novel gene, TMEM2. Gene. 2000 Apr 4;246(1-2):265-74
Latest

J:346912 Huang H, et al., Hyaluronan degradation by HYAL2 is essential for odontoblastic differentiation and migration of mouse dental papilla cells. Matrix Biol. 2024 Mar 13;

TSS for Cemip2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155513	Chr19:21754889-21754894 (+)	-814 bp
Tssr5460	Chr19:21755661-21755664 (+)	-43 bp
Tssr155514	Chr19:21755671-21755682 (+)	-29 bp
Tssr155515	Chr19:21755689-21755727 (+)	2 bp
Tssr155516	Chr19:21755729-21755738 (+)	28 bp
Tssr155517	Chr19:21755740-21755756 (+)	42 bp
Tssr155518	Chr19:21756006-21756015 (+)	305 bp
Tssr155519	Chr19:21762166-21762173 (+)	6,464 bp
Tssr155520	Chr19:21770141-21770163 (+)	14,446 bp
Tssr155521	Chr19:21770180-21770205 (+)	14,487 bp
Tssr155522	Chr19:21770616-21770620 (+)	14,912 bp
Tssr155523	Chr19:21817323-21817328 (+)	61,620 bp
Tssr155524	Chr19:21817619-21817624 (+)	61,916 bp
Tssr155525	Chr19:21828781-21828794 (+)	73,082 bp
Tssr155526	Chr19:21835439-21835445 (+)	79,736 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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