Arhgap1 MGI Mouse Gene Detail - MGI:2445003 - Rho GTPase activating protein 1

Symbol

Arhgap1
Name

Rho GTPase activating protein 1
Synonyms

B230365D05Rik, Cdc42GAP, p50rhoGAP

Feature Type

protein coding gene
IDs

MGI:2445003
NCBI Gene: 228359
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr2:91480463-91502670 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 50.63 cM
Mapping Data

2 experiments

SNPs within 2kb

610 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2445003	protein coding gene	Chr2:91480205-91502671 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026154	protein coding gene	Chr2:92999444-93028174 (+)
A/J	MGP_AJ_G0026115	protein coding gene	Chr2:89269477-89292028 (+)
AKR/J	MGP_AKRJ_G0026096	protein coding gene	Chr2:91737909-91760439 (+)
BALB/cJ	MGP_BALBcJ_G0026124	protein coding gene	Chr2:89453445-89475986 (+)
C3H/HeJ	MGP_C3HHeJ_G0025875	protein coding gene	Chr2:92020424-92043591 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026575	protein coding gene	Chr2:96252167-96276724 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023966	protein coding gene	Chr2:85766991-85790017 (+)
CAST/EiJ	MGP_CASTEiJ_G0025340	protein coding gene	Chr2:92569537-92592911 (+)
CBA/J	MGP_CBAJ_G0025853	protein coding gene	Chr2:99556192-99578786 (+)
DBA/2J	MGP_DBA2J_G0025989	protein coding gene	Chr2:88872143-88894595 (+)
FVB/NJ	MGP_FVBNJ_G0025952	protein coding gene	Chr2:87970914-87993362 (+)
LP/J	MGP_LPJ_G0026093	protein coding gene	Chr2:93216765-93239550 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025978	protein coding gene	Chr2:102575210-102599089 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026629	protein coding gene	Chr2:91811391-91835265 (+)
PWK/PhJ	MGP_PWKPhJ_G0025075	protein coding gene	Chr2:88604394-88628087 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024876	protein coding gene	Chr2:91392407-91413678 (+)
WSB/EiJ	MGP_WSBEiJ_G0025407	protein coding gene	Chr2:92411433-92434322 (+)

Human Ortholog

ARHGAP1, Rho GTPase activating protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGAP1, Rho GTPase activating protein 1
Synonyms

CDC42GAP, p50rhoGAP, RHOGAP, RHOGAP1
Links

HGNC:673

NCBI Gene ID: 392

neXtProt AC: NX_Q07960

UniProt: Q07960
Chr Location

11p11.2; chr11:46677080-46700619 (-) GRCh38

MGI Vertebrate Homology

Arhgap1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARHGAP1
Gene Tree

Arhgap1

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Phenotype Summary

35 phenotypes from 1 allele in 2 genetic backgrounds
1 phenotype from multigenic genotypes
2 images
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

23
Radiation induced

1
Targeted

3
Genomic Mutations

4 involving Arhgap1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display incomplete penetrance of postnatal lethality, increased apoptosis, and growth retardation.

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All GO Annotations

23
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

140
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ARHGAP1

Xenbase arhgap1

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All Sequences

91
RefSeq

25
UniProt

5
CCDS

CCDS16437.1, CCDS50641.1

Ensembl

ENSMUSG00000027247 (Evidence)
NCBI Gene

228359

			Length	Strain/Species	Flank
genomic	228359	NCBI Gene Model \| MGI Sequence Detail	22208	C57BL/6J	± kb
transcript	NM_146124	RefSeq \| MGI Sequence Detail	3113	C57BL/6
polypeptide	Q5FWK3	UniProt \| EBI \| MGI Sequence Detail	439	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004218 Rho GTPase-activating protein 1

(term hierarchy)
InterPro Domains

IPR001251 CRAL-TRIO lipid binding domain

IPR036865 CRAL-TRIO lipid binding domain superfamily

IPR049592 Rho GTPase-activating protein 1, RhoGAP domain

IPR000198 Rho GTPase-activating protein domain

IPR008936 Rho GTPase activation protein

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All nucleic 141

cDNA 141

Microarray probesets 4

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MGI:2139453

Summaries

All 49

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 18
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Arhgap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18909	Chr2:91480461-91480478 (+)	7 bp
Tssr18910	Chr2:91480514-91480582 (+)	85 bp
Tssr18911	Chr2:91494270-91494293 (+)	13,819 bp
Tssr18912	Chr2:91494299-91494318 (+)	13,846 bp
Tssr18913	Chr2:91494326-91494365 (+)	13,883 bp
Tssr18914	Chr2:91494465-91494503 (+)	14,021 bp
Tssr18915	Chr2:91494678-91494695 (+)	14,224 bp
Tssr18916	Chr2:91494755-91494791 (+)	14,310 bp
Tssr18917	Chr2:91494797-91494840 (+)	14,356 bp
Tssr18918	Chr2:91494927-91494950 (+)	14,476 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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