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Slc38a8 Gene Detail
Summary
  • Symbol
    Slc38a8
  • Name
    solute carrier family 38, member 8
  • Synonyms
    LOC234788
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685433
    NCBI Gene: 234788
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:120206341-120228437 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 67.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    884 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685433
 protein coding gene Chr8:120206313-120228503 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034183
 protein coding gene Chr8:122793093-122828666 (-)
A/J MGP_AJ_G0034163
 protein coding gene Chr8:117751037-117774976 (-)
AKR/J MGP_AKRJ_G0034090
 protein coding gene Chr8:121165751-121189593 (-)
BALB/cJ MGP_BALBcJ_G0034157
 protein coding gene Chr8:117953261-117977356 (-)
C3H/HeJ MGP_C3HHeJ_G0033868
 protein coding gene Chr8:121898658-121921753 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034677
 protein coding gene Chr8:126908369-126944422 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031619
 protein coding gene Chr8:110642234-110664511 (-)
CAST/EiJ MGP_CASTEiJ_G0033195
 protein coding gene Chr8:121837690-121861545 (-)
CBA/J MGP_CBAJ_G0033841
 protein coding gene Chr8:131523712-131554805 (-)
DBA/2J MGP_DBA2J_G0033997
 protein coding gene Chr8:116973717-116996215 (-)
FVB/NJ MGP_FVBNJ_G0033940
 protein coding gene Chr8:115999619-116021352 (-)
LP/J MGP_LPJ_G0034086
 protein coding gene Chr8:122945516-122972628 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033987
 protein coding gene Chr8:133979967-134001751 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034695
 protein coding gene Chr8:121316613-121343369 (-)
PWK/PhJ MGP_PWKPhJ_G0032897
 protein coding gene Chr8:116724914-116747770 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032737
 protein coding gene Chr8:120020316-120043406 (-)
WSB/EiJ MGP_WSBEiJ_G0033311
 protein coding gene Chr8:122034973-122060331 (-)



Homology
more
  • Human Ortholog
    SLC38A8, solute carrier family 38 member 8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC38A8, solute carrier family 38 member 8
  • Synonyms
    FHASD, FVH2, SNAT8
  • Links
    NCBI Gene ID: 146167
    neXtProt AC: NX_A6NNN8
    UniProt: A6NNN8

  • Chr Location
    16q23.3; chr16:84009667-84043372 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slc38a8 mouse models; 1 with human SLC38A8 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced susceptibility to FMDV or EV71-infection with reduced aspartate response, viral titers, and mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    12
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034224 Ensembl Gene Model | MGI Sequence Detail 22097 C57BL/6J ±  kb
    transcript ENSMUST00000036748 Ensembl | MGI Sequence Detail 2623 Not Applicable  
    polypeptide ENSMUSP00000038438 Ensembl | MGI Sequence Detail 432 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 12
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory