Drosha MGI Mouse Gene Detail - MGI:1261425 - drosha, ribonuclease type III

Symbol

Drosha
Name

drosha, ribonuclease type III
Synonyms

1110013A17Rik, Etohi2, Rnasen

Feature Type

protein coding gene
IDs

MGI:1261425
NCBI Gene: 14000
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr15:12824901-12935377 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 5.99 cM
Mapping Data

2 experiments

SNPs within 2kb

3330 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1261425	protein coding gene	Chr15:12824893-12935377 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021740	protein coding gene	Chr15:10073524-10183520 (+)
A/J	MGP_AJ_G0021700	protein coding gene	Chr15:9757887-9874691 (+)
AKR/J	MGP_AKRJ_G0021678	protein coding gene	Chr15:10039894-10159798 (+)
BALB/cJ	MGP_BALBcJ_G0021707	protein coding gene	Chr15:9667407-9783359 (+)
C3H/HeJ	MGP_C3HHeJ_G0021483	protein coding gene	Chr15:9977505-10095434 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022146	protein coding gene	Chr15:10434633-10546627 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019687	protein coding gene	Chr15:9284646-9390548 (+)
CAST/EiJ	MGP_CASTEiJ_G0020999	protein coding gene	Chr15:10097079-10211943 (+)
CBA/J	MGP_CBAJ_G0021452	protein coding gene	Chr15:10755802-10867837 (+)
DBA/2J	MGP_DBA2J_G0021576	protein coding gene	Chr15:9617527-9723593 (+)
FVB/NJ	MGP_FVBNJ_G0021554	protein coding gene	Chr15:9469359-9579278 (+)
LP/J	MGP_LPJ_G0021644	protein coding gene	Chr15:10011302-10127509 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021579	protein coding gene	Chr15:10960195-11073299 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022169	protein coding gene	Chr15:10034672-10146311 (+)
PWK/PhJ	MGP_PWKPhJ_G0020742	protein coding gene	Chr15:9813585-9921720 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020580	protein coding gene	Chr15:9967440-10081363 (+)
WSB/EiJ	MGP_WSBEiJ_G0021055	protein coding gene	Chr15:10020143-10130415 (+)

Human Ortholog

DROSHA, drosha ribonuclease III

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DROSHA, drosha ribonuclease III
Synonyms

ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN
Links

HGNC:17904

NCBI Gene ID: 29102

neXtProt AC: NX_Q9NRR4

UniProt: Q9NRR4
Chr Location

5p13.3; chr5:31400494-31532196 (-) GRCh38

MGI Vertebrate Homology

Drosha stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DROSHA
Gene Tree

Drosha

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Phenotype Summary

68 phenotypes from 6 alleles in 8 genetic backgrounds
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

75
Endonuclease-mediated

3
Gene trapped

64
Targeted

8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

96 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice heterozygous for a knock-out allele and a conditional allele activated in the immune system exhibit increased inflammation in multiple systems, cachexia and premature death. Conditional homozygous KO in the embryonic nephrogenic zone causes kidney developmental anomalies and perinatal mortality.

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All GO Annotations

46
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

872
Tissues

64
cDNA Data

186
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA DROSHA

Xenbase drosha

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All Sequences

72
RefSeq

7
UniProt

8
CCDS

CCDS49583.1

Ensembl

ENSMUSG00000022191 (Evidence)
NCBI Gene

14000

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022191	Ensembl Gene Model \| MGI Sequence Detail	110477	C57BL/6J	± kb
transcript	ENSMUST00000090292	Ensembl \| MGI Sequence Detail	4519	Not Applicable
polypeptide	ENSMUSP00000087762	Ensembl \| MGI Sequence Detail	1373	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000014059 ribonuclease 3

(term hierarchy)
EC

3.1.26.3
InterPro Domains

IPR014720 Double-stranded RNA-binding domain

IPR011907 Ribonuclease III

IPR000999 Ribonuclease III domain

IPR036389 Ribonuclease III, endonuclease domain superfamily

IPR044442 RNase III, double-stranded RNA binding domain, animal

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All nucleic 193

cDNA 187

Primer pair 5

Other 1

Microarray probesets 7

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MGI:1915895, MGI:2146099

Summaries

All 97

Developmental Gene Expression 11

Gene Ontology 16

Phenotypes 39
Earliest

J:46302 Rout UK, et al., Ethanol-induced intracellular calcium mobilization rapidly alters gene expression in the mouse blastocyst. Cell Calcium. 1997 Dec;22(6):463-74
Latest

J:326568 Guo M, et al., Uncoupling transcription and translation through miRNA-dependent poly(A) length control in haploid male germ cells. Development. 2022 Jun 15;149(12):dev199573

TSS for Drosha:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130744	Chr15:12824908-12824919 (+)	13 bp
Tssr130745	Chr15:12824927-12824969 (+)	47 bp
Tssr130746	Chr15:12824970-12824993 (+)	81 bp
Tssr130747	Chr15:12833619-12833677 (+)	8,747 bp
Tssr130748	Chr15:12833689-12833707 (+)	8,797 bp
Tssr130749	Chr15:12918478-12918493 (+)	93,585 bp
Tssr130750	Chr15:12924091-12924101 (+)	99,195 bp
Tssr130751	Chr15:12924131-12924149 (+)	99,239 bp
Tssr130752	Chr15:12924150-12924176 (+)	99,262 bp
Tssr130753	Chr15:12924178-12924191 (+)	99,284 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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