Tmem232 MGI Mouse Gene Detail - MGI:2685786

Symbol

Tmem232
Name

transmembrane protein 232
Synonyms

E130009J12Rik, LOC381107

Feature Type

protein coding gene
IDs

MGI:2685786
NCBI Gene: 381107
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr17:65562994-65847777 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 34.90 cM
Mapping Data

1 experiment

SNPs within 2kb

8544 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685786	protein coding gene	Chr17:65562994-65848080 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023976	protein coding gene	Chr17:67359912-67665339 (-)
A/J	MGP_AJ_G0023934	protein coding gene	Chr17:65373300-65637628 (-)
AKR/J	MGP_AKRJ_G0023903	protein coding gene	Chr17:66269462-66564806 (-)
BALB/cJ	MGP_BALBcJ_G0023935	protein coding gene	Chr17:65287786-65584198 (-)
C3H/HeJ	MGP_C3HHeJ_G0023699	protein coding gene	Chr17:67155390-67450613 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024381	protein coding gene	Chr17:69998070-70294564 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021827	protein coding gene	Chr17:61443951-61683111 (-)
CAST/EiJ	MGP_CASTEiJ_G0023181	protein coding gene	Chr17:67509063-67787363 (-)
CBA/J	MGP_CBAJ_G0023675	protein coding gene	Chr17:72752713-73043941 (-)
DBA/2J	MGP_DBA2J_G0023803	protein coding gene	Chr17:64116422-64398070 (-)
FVB/NJ	MGP_FVBNJ_G0023769	protein coding gene	Chr17:63607367-63887158 (-)
LP/J	MGP_LPJ_G0023885	protein coding gene	Chr17:68107165-68392833 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023797	protein coding gene	Chr17:72836345-73150892 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024425	protein coding gene	Chr17:66732094-67028131 (-)
PWK/PhJ	MGP_PWKPhJ_G0022927	protein coding gene	Chr17:63384837-63659835 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022738	protein coding gene	Chr17:63420744-63699133 (-)
WSB/EiJ	MGP_WSBEiJ_G0023247	protein coding gene	Chr17:67437477-67729431 (-)

Human Ortholog

TMEM232, transmembrane protein 232

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM232, transmembrane protein 232
Links

HGNC:37270

NCBI Gene ID: 642987

neXtProt AC: NX_C9JQI7

UniProt: C9JQI7
Chr Location

5q22.1; chr5:110289233-110738956 (-) GRCh38

MGI Vertebrate Homology

Tmem232 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM232
Gene Tree

Tmem232

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

4
Gene trapped

2
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null males are infertile, exhibit reduced sperm count, abnormal sperm flagellum morphology and reduced sperm motility.

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All GO Annotations

14
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

9

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem232

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All Sequences

64
RefSeq

15
UniProt

4
CCDS

CCDS28940.1, CCDS89134.1, CCDS89135.1

Ensembl

ENSMUSG00000045036 (Evidence)
NCBI Gene

381107

			Length	Strain/Species	Flank
genomic	ENSMUSG00000045036	Ensembl Gene Model \| MGI Sequence Detail	284784	C57BL/6J	± kb
transcript	ENSMUST00000086722	Ensembl \| MGI Sequence Detail	2588	Not Applicable
polypeptide	ENSMUSP00000083927	Ensembl \| MGI Sequence Detail	675	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000032576 transmembrane protein 232

(term hierarchy)
InterPro Domains

IPR031747 Transmembrane protein 232

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All nucleic 9

cDNA 9

Microarray probesets 3

Summaries

All 28

Gene Ontology 4

Phenotypes 6
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:338029 He X, et al., Deficiency of the Tmem232 Gene Causes Male Infertility with Morphological Abnormalities of the Sperm Flagellum in Mice. Cells. 2023 Jun 13;12(12)

TSS for Tmem232:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr149049	Chr17:65847780-65847787 (-)	-7 bp
Tssr149048	Chr17:65847742-65847768 (-)	22 bp
Tssr149047	Chr17:65817049-65817079 (-)	30,713 bp
Tssr149046	Chr17:65817043-65817046 (-)	30,732 bp
Tssr149045	Chr17:65817019-65817038 (-)	30,748 bp
Tssr149044	Chr17:65673823-65673825 (-)	173,953 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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