Trappc1 MGI Mouse Gene Detail - MGI:1098727 - trafficking protein particle complex 1

Symbol

Trappc1
Name

trafficking protein particle complex 1
Synonyms

BET5, D11Ertd172e, MUM2

Feature Type

protein coding gene
IDs

MGI:1098727
NCBI Gene: 245828
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:69214812-69216619 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.51 cM
Mapping Data

1 experiment

SNPs within 2kb

104 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098727	protein coding gene	Chr11:69214806-69216619 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018526	protein coding gene	Chr11:69745747-69747560 (+)
A/J	MGP_AJ_G0018495	protein coding gene	Chr11:67122823-67124636 (+)
AKR/J	MGP_AKRJ_G0018464	protein coding gene	Chr11:69122054-69123871 (+)
BALB/cJ	MGP_BALBcJ_G0018466	protein coding gene	Chr11:67441789-67443602 (+)
C3H/HeJ	MGP_C3HHeJ_G0018279	protein coding gene	Chr11:69146682-69148495 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018918	protein coding gene	Chr11:71858395-71860208 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016562	protein coding gene	Chr11:64053050-64054853 (+)
CAST/EiJ	MGP_CASTEiJ_G0017835	protein coding gene	Chr11:69387243-69389055 (+)
CBA/J	MGP_CBAJ_G0018253	protein coding gene	Chr11:75074684-75076497 (+)
DBA/2J	MGP_DBA2J_G0018362	protein coding gene	Chr11:66717037-66718850 (+)
FVB/NJ	MGP_FVBNJ_G0018352	protein coding gene	Chr11:66340436-66342249 (+)
LP/J	MGP_LPJ_G0018433	protein coding gene	Chr11:70316077-70317890 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018375	protein coding gene	Chr11:75692505-75694318 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018959	protein coding gene	Chr11:69381276-69383089 (+)
PWK/PhJ	MGP_PWKPhJ_G0017610	protein coding gene	Chr11:67356800-67358614 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017398	protein coding gene	Chr11:69203787-69205603 (+)
WSB/EiJ	MGP_WSBEiJ_G0017889	protein coding gene	Chr11:69058654-69060467 (+)

Human Ortholog

TRAPPC1, trafficking protein particle complex subunit 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRAPPC1, trafficking protein particle complex subunit 1
Synonyms

BET5, MUM2
Links

HGNC:19894

NCBI Gene ID: 58485

neXtProt AC: NX_Q9Y5R8

UniProt: Q9Y5R8
Chr Location

17p13.1; chr17:7930345-7932123 (-) GRCh38

MGI Vertebrate Homology

Trappc1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRAPPC1
Gene Tree

Trappc1

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

5
Targeted

1
Genomic Mutations

1 involving Trappc1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

722
Tissues

9
cDNA Data

71
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trappc1

ZFIN trappc1

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All Sequences

41
RefSeq

2
UniProt

4
CCDS

CCDS24889.1

Ensembl

ENSMUSG00000049299 (Evidence)
NCBI Gene

245828

			Length	Strain/Species	Flank
genomic	245828	NCBI Gene Model \| MGI Sequence Detail	1808	C57BL/6J	± kb
transcript	NM_001024206	RefSeq \| MGI Sequence Detail	745	ZRU/MplStud
polypeptide	Q5NCF2	UniProt \| EBI \| MGI Sequence Detail	145	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016611 trafficking protein particle complex subunit 1

(term hierarchy)
PDB

2J3T
InterPro Domains

IPR011012 Longin-like domain superfamily

IPR007233 Trafficking protein particle complex subunit

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All nucleic 74

cDNA 72

Primer pair 2

Microarray probesets 2

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:346999 Zhang Z, et al., Trappc1 intrinsically prevents ferroptosis of naive T cells to avoid spontaneous autoinflammatory disease in mice. Eur J Immunol. 2024 Mar;54(3):e2350836

TSS for Trappc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102425	Chr11:69214789-69214869 (+)	17 bp
Tssr102426	Chr11:69214881-69214891 (+)	74 bp
Tssr102427	Chr11:69214895-69214937 (+)	104 bp
Tssr102428	Chr11:69214971-69214982 (+)	165 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24