Cracd MGI Mouse Gene Detail - MGI:2444817 - capping protein inhibiting regulator of actin

Symbol

Cracd
Name

capping protein inhibiting regulator of actin
Synonyms

2810489J07Rik, 4930529A19Rik, 4931405B09Rik, C530008M17Rik, mKIAA1211

Feature Type

protein coding gene
IDs

MGI:2444817
NCBI Gene: 320827
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr5:76804359-77021392 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 41.34 cM, cytoband E1
Mapping Data

3 experiments

SNPs within 2kb

6798 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444817	protein coding gene	Chr5:76803225-77021393 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029647	protein coding gene	Chr5:76854514-77084476 (+)
A/J	MGP_AJ_G0029615	protein coding gene	Chr5:73925001-74145288 (+)
AKR/J	MGP_AKRJ_G0029563	protein coding gene	Chr5:76335524-76561921 (+)
BALB/cJ	MGP_BALBcJ_G0029624	protein coding gene	Chr5:74655379-74876217 (+)
C3H/HeJ	MGP_C3HHeJ_G0029347	protein coding gene	Chr5:76704961-76934736 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030078	protein coding gene	Chr5:79920546-80160173 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027319	protein coding gene	Chr5:69553289-69775349 (+)
CAST/EiJ	MGP_CASTEiJ_G0028755	protein coding gene	Chr5:75905218-76138911 (+)
CBA/J	MGP_CBAJ_G0029316	protein coding gene	Chr5:82556795-82813498 (+)
DBA/2J	MGP_DBA2J_G0029461	protein coding gene	Chr5:73983163-74203086 (+)
FVB/NJ	MGP_FVBNJ_G0029422	protein coding gene	Chr5:73182382-73401573 (+)
LP/J	MGP_LPJ_G0029548	protein coding gene	Chr5:77292537-77523151 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029450	protein coding gene	Chr5:85714283-85960311 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030111	protein coding gene	Chr5:75881498-76108462 (+)
PWK/PhJ	MGP_PWKPhJ_G0028478	protein coding gene	Chr5:73000109-73219545 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028313	protein coding gene	Chr5:75239934-75470197 (+)
WSB/EiJ	MGP_WSBEiJ_G0028835	protein coding gene	Chr5:76204670-76442010 (+)

Human Ortholog

CRACD, capping protein inhibiting regulator of actin dynamics

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRACD, capping protein inhibiting regulator of actin dynamics
Synonyms

CRAD, KIAA1211
Links

HGNC:29219

NCBI Gene ID: 57482

neXtProt AC: NX_Q6ZU35

UniProt: Q6ZU35
Chr Location

4q12; chr4:56049098-56330609 (+) GRCh38

MGI Vertebrate Homology

Cracd stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CRACD
Gene Tree

Cracd

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

1
Spontaneous

1
Genomic Mutations

4 involving Cracd
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

54 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

807
Tissues

83
cDNA Data

17
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cracd

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All Sequences

98
RefSeq

37
UniProt

1
CCDS

CCDS51526.1

Ensembl

ENSMUSG00000036377 (Evidence)
NCBI Gene

320827

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036377	Ensembl Gene Model \| MGI Sequence Detail	217034	C57BL/6J	± kb
transcript	ENSMUST00000238963	Ensembl \| MGI Sequence Detail	7096	Not Applicable
polypeptide	ENSMUSP00000159046	Ensembl \| MGI Sequence Detail	1376	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000059885 capping protein-inhibiting regulator of actin dynamics

(term hierarchy)

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All nucleic 21

Genomic 1

cDNA 17

Primer pair 3

Microarray probesets 12

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MGI:1918189, MGI:1920065, MGI:1922397, MGI:6390555

Summaries

All 41

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 11
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:351307 Kim B, et al., CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma. Cell Rep. 2024 Jun 25;43(6):114286

TSS for Cracd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46732	Chr5:76825081-76825117 (+)	20,740 bp
Tssr46733	Chr5:76825121-76825126 (+)	20,765 bp
Tssr46734	Chr5:76825142-76825152 (+)	20,788 bp
Tssr46735	Chr5:76957720-76957736 (+)	153,369 bp
Tssr46736	Chr5:76957811-76957857 (+)	153,475 bp
Tssr46737	Chr5:76957859-76957904 (+)	153,523 bp
Tssr46738	Chr5:76970201-76970265 (+)	165,874 bp
Tssr46739	Chr5:76970320-76970328 (+)	165,965 bp
Tssr46740	Chr5:76970340-76970351 (+)	165,987 bp
Tssr46741	Chr5:76970371-76970388 (+)	166,021 bp
Tssr46742	Chr5:76970404-76970418 (+)	166,052 bp
Tssr46743	Chr5:76988444-76988484 (+)	184,105 bp
Tssr46744	Chr5:77002897-77002908 (+)	198,544 bp
Tssr46745	Chr5:77003337-77003338 (+)	198,979 bp
Tssr46746	Chr5:77004497-77004513 (+)	200,146 bp
Tssr46747	Chr5:77004600-77004617 (+)	200,250 bp
Tssr46748	Chr5:77006571-77006585 (+)	202,219 bp
Tssr46749	Chr5:77006587-77006599 (+)	202,234 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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