About   Help   FAQ
Ccdc88a Gene Detail
Summary
  • Symbol
    Ccdc88a
  • Name
    coiled coil domain containing 88A
  • Synonyms
    A430106J12Rik, C130096N06Rik, C330012F17Rik, D130005J21Rik, Girdin, GIV, HkRP1, mKIAA1212
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925177
    NCBI Gene: 108686
  • Alliance
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:29323658-29460808 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 16.61 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2408 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925177
protein coding gene Chr11:29323521-29460808 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018106
protein coding gene Chr11:27367848-27515536 (+)
A/J MGP_AJ_G0018078
protein coding gene Chr11:26370880-26504131 (+)
AKR/J MGP_AKRJ_G0018043
protein coding gene Chr11:27229677-27366968 (+)
BALB/cJ MGP_BALBcJ_G0018046
protein coding gene Chr11:26575894-26708271 (+)
C3H/HeJ MGP_C3HHeJ_G0017860
protein coding gene Chr11:27140223-27277083 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018499
protein coding gene Chr11:28321208-28461657 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016156
protein coding gene Chr11:25011531-25147885 (+)
CAST/EiJ MGP_CASTEiJ_G0017422
protein coding gene Chr11:27184087-27336706 (+)
CBA/J MGP_CBAJ_G0017834
protein coding gene Chr11:29645167-29805032 (+)
DBA/2J MGP_DBA2J_G0017944
protein coding gene Chr11:26227603-26363836 (+)
FVB/NJ MGP_FVBNJ_G0017936
protein coding gene Chr11:26031064-26163026 (+)
LP/J MGP_LPJ_G0018016
protein coding gene Chr11:27641119-27775300 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017962
protein coding gene Chr11:30714401-30889300 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018539
protein coding gene Chr11:27333935-27463481 (+)
PWK/PhJ MGP_PWKPhJ_G0017204
protein coding gene Chr11:26315934-26455540 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016999
protein coding gene Chr11:27014594-27153113 (+)
WSB/EiJ MGP_WSBEiJ_G0017475
protein coding gene Chr11:27032222-27167354 (+)



Homology
more
  • Human Ortholog
    CCDC88A, coiled-coil domain containing 88A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCDC88A, coiled-coil domain containing 88A
  • Synonyms
    APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212, PEHO, PEHOL
  • Links
    NCBI Gene ID: 55704
    neXtProt AC: NX_Q3V6T2
    UniProt: Q3V6T2

  • Chr Location
    2p16.1; chr2:55287842-55419895 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 4 alleles in 3 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit postnatal weight loss, reduced angiogenesis, and premature death by P25.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032740 Ensembl Gene Model | MGI Sequence Detail 137151 C57BL/6J ±  kb
    transcript ENSMUST00000239407 Ensembl | MGI Sequence Detail 6051 Not Applicable  
    polypeptide ENSMUSP00000159356 Ensembl | MGI Sequence Detail 2016 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 27
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1915538, MGI:2144295, MGI:2442608, MGI:2443604
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:335041 Wang H, et al., The signaling protein GIV/Girdin mediates the Nephrin-dependent insulin secretion of pancreatic islet beta cells in response to high glucose. J Biol Chem. 2023 Feb 21;299(4):103045

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    10/22/2024
    MGI 6.24
    The Jackson Laboratory