Utp18 MGI Mouse Gene Detail - MGI:1923402 - UTP18 small subunit processome component

Symbol

Utp18
Name

UTP18 small subunit processome component
Synonyms

6230425C22Rik, Wdr50

Feature Type

protein coding gene
IDs

MGI:1923402
NCBI Gene: 217109
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:93750069-93776592 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 58.84 cM
Mapping Data

1 experiment

SNPs within 2kb

673 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923402	protein coding gene	Chr11:93750069-93776592 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018944	protein coding gene	Chr11:95886385-95913865 (-)
A/J	MGP_AJ_G0018912	protein coding gene	Chr11:92086735-92114637 (-)
AKR/J	MGP_AKRJ_G0018882	protein coding gene	Chr11:94959254-94986439 (-)
BALB/cJ	MGP_BALBcJ_G0018885	protein coding gene	Chr11:92514996-92541490 (-)
C3H/HeJ	MGP_C3HHeJ_G0018699	protein coding gene	Chr11:95031307-95058493 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019337	protein coding gene	Chr11:98877434-98906581 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016968	protein coding gene	Chr11:89574810-89603308 (-)
CAST/EiJ	MGP_CASTEiJ_G0018254	protein coding gene	Chr11:95714178-95741583 (-)
CBA/J	MGP_CBAJ_G0018670	protein coding gene	Chr11:102988778-103015990 (-)
DBA/2J	MGP_DBA2J_G0018778	protein coding gene	Chr11:91650336-91677497 (-)
FVB/NJ	MGP_FVBNJ_G0018767	protein coding gene	Chr11:91069890-91096703 (-)
LP/J	MGP_LPJ_G0018848	protein coding gene	Chr11:96435030-96462235 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018794	protein coding gene	Chr11:103043045-103071823 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019377	protein coding gene	Chr11:95142447-95171849 (-)
PWK/PhJ	MGP_PWKPhJ_G0018024	protein coding gene	Chr11:92570247-92597930 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017814	protein coding gene	Chr11:94837392-94862944 (-)
WSB/EiJ	MGP_WSBEiJ_G0018303	protein coding gene	Chr11:95023941-95055290 (-)

Human Ortholog

UTP18, UTP18 small subunit processome component

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UTP18, UTP18 small subunit processome component
Synonyms

CGI-48, WDR50
Links

HGNC:24274

NCBI Gene ID: 51096

neXtProt AC: NX_Q9Y5J1

UniProt: Q9Y5J1
Chr Location

17q21.33; chr17:51260546-51297936 (+) GRCh38

MGI Vertebrate Homology

Utp18 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UTP18
Gene Tree

Utp18

less

References

1 with disease annotations

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

2
Gene trapped

6
Targeted

3
Genomic Mutations

3 involving Utp18
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available

less

All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

52
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase utp18

less

All Sequences

41
RefSeq

2
UniProt

4
CCDS

CCDS25245.1

Ensembl

ENSMUSG00000054079 (Evidence)
NCBI Gene

217109

			Length	Strain/Species	Flank
genomic	217109	NCBI Gene Model \| MGI Sequence Detail	26524	C57BL/6J	± kb
transcript	NM_001013375	RefSeq \| MGI Sequence Detail	2613	C57BL/6
polypeptide	Q5SSI6	UniProt \| EBI \| MGI Sequence Detail	552	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000017204 U3 small nucleolar RNA-associated protein 18

(term hierarchy)
InterPro Domains

IPR045161 U3 small nucleolar RNA-associated protein 18

IPR001680 WD40 repeat

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

Q5SSI6 1 site, 1 O-linked glycan (1 site)

less

All nucleic 53

cDNA 52

Primer pair 1

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 1

Diseases 1

Gene Ontology 6

Phenotypes 13
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:174216 Terzian T, et al., Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug;224(4):540-52

TSS for Utp18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110111	Chr11:93777328-93777338 (-)	-741 bp
Tssr110110	Chr11:93776917-93776966 (-)	-350 bp
Tssr110109	Chr11:93776578-93776599 (-)	3 bp
Tssr110108	Chr11:93776550-93776567 (-)	33 bp
Tssr110107	Chr11:93776486-93776545 (-)	76 bp
Tssr110106	Chr11:93775088-93775091 (-)	1,502 bp
Tssr110105	Chr11:93750556-93750561 (-)	26,033 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24