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Tns3 Gene Detail
Summary
  • Symbol
    Tns3
  • Name
    tensin 3
  • Synonyms
    F830010I22Rik, TEM6, Tens1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443012
    NCBI Gene: 319939
  • Alliance
    gene page
  • Transcription Start Sites
    65 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:8381652-8614681 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 4.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7767 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443012
 protein coding gene Chr11:8381652-8614758 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018035
 protein coding gene Chr11:5644141-5888236 (-)
A/J MGP_AJ_G0018008
 protein coding gene Chr11:5405360-5643368 (-)
AKR/J MGP_AKRJ_G0017972
 protein coding gene Chr11:5599222-5836518 (-)
BALB/cJ MGP_BALBcJ_G0017976
 protein coding gene Chr11:5394211-5628049 (-)
C3H/HeJ MGP_C3HHeJ_G0017789
 protein coding gene Chr11:5518594-5762099 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018428
 protein coding gene Chr11:5792646-6036509 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016086
 protein coding gene Chr11:5144855-5378242 (-)
CAST/EiJ MGP_CASTEiJ_G0017351
 protein coding gene Chr11:5514695-5783217 (-)
CBA/J MGP_CBAJ_G0017764
 protein coding gene Chr11:6306912-6569119 (-)
DBA/2J MGP_DBA2J_G0017874
 protein coding gene Chr11:5339954-5578594 (-)
FVB/NJ MGP_FVBNJ_G0017866
 protein coding gene Chr11:5321228-5554254 (-)
LP/J MGP_LPJ_G0017945
 protein coding gene Chr11:5672742-5922791 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017892
 protein coding gene Chr11:5895096-6145504 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018468
 protein coding gene Chr11:5728532-5976809 (-)
PWK/PhJ MGP_PWKPhJ_G0017131
 protein coding gene Chr11:5338891-5575447 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016928
 protein coding gene Chr11:5594297-5836273 (-)
WSB/EiJ MGP_WSBEiJ_G0017405
 protein coding gene Chr11:5488623-5735586 (-)



Homology
more
  • Human Ortholog
    TNS3, tensin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNS3, tensin 3
  • Synonyms
    TEM6, TENS1
  • Links
    NCBI Gene ID: 64759
    neXtProt AC: NX_Q68CZ2
    UniProt: Q68CZ2

  • Chr Location
    7p12.3; chr7:47275154-47582586 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit one third postnatal lethality, reduced body weight, growth retardation, smaller digestive tracts with defects in villi and enterocyte differentiation, abnormal lung morphology, and thinner bones with decreased chondrocyte proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    821
  • Tissues
    22
  • cDNA Data
    67
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020422 Ensembl Gene Model | MGI Sequence Detail 233030 C57BL/6J ±  kb
    transcript ENSMUST00000239111 Ensembl | MGI Sequence Detail 7629 Not Applicable  
    polypeptide ENSMUSP00000158940 Ensembl | MGI Sequence Detail 1589 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 67

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2652851
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory