Adad1 MGI Mouse Gene Detail - MGI:103258 - adenosine deaminase domain containing 1

Symbol

Adad1
Name

adenosine deaminase domain containing 1

Feature Type

protein coding gene
IDs

MGI:103258
NCBI Gene: 21744
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr3:37117805-37165661 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 18.30 cM, cytoband B
Mapping Data

1 experiment

SNPs within 2kb

231 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103258	protein coding gene	Chr3:37117676-37176079 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027165	protein coding gene	Chr3:34905839-34966720 (+)
A/J	MGP_AJ_G0027125	protein coding gene	Chr3:34216282-34271775 (+)
AKR/J	MGP_AKRJ_G0027094	protein coding gene	Chr3:34853184-34909965 (+)
BALB/cJ	MGP_BALBcJ_G0027137	protein coding gene	Chr3:33964519-34022097 (+)
C3H/HeJ	MGP_C3HHeJ_G0026880	protein coding gene	Chr3:34907445-34967417 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027583	protein coding gene	Chr3:36541535-36597876 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024944	protein coding gene	Chr3:31896778-31951166 (+)
CAST/EiJ	MGP_CASTEiJ_G0026333	protein coding gene	Chr3:34777680-34831270 (+)
CBA/J	MGP_CBAJ_G0026857	protein coding gene	Chr3:37524336-37574381 (+)
DBA/2J	MGP_DBA2J_G0026991	protein coding gene	Chr3:33655271-33709630 (+)
FVB/NJ	MGP_FVBNJ_G0026959	protein coding gene	Chr3:33097662-33152530 (+)
LP/J	MGP_LPJ_G0027103	protein coding gene	Chr3:35678808-35741446 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026979	protein coding gene	Chr3:39987673-40052623 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027642	protein coding gene	Chr3:34702125-34761395 (+)
PWK/PhJ	MGP_PWKPhJ_G0026066	protein coding gene	Chr3:33337670-33396102 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025878	protein coding gene	Chr3:34069000-34114064 (+)
WSB/EiJ	MGP_WSBEiJ_G0026407	protein coding gene	Chr3:34722657-34786870 (+)

Human Ortholog

ADAD1, adenosine deaminase domain containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADAD1, adenosine deaminase domain containing 1
Synonyms

Tenr
Links

HGNC:30713

NCBI Gene ID: 132612

neXtProt AC: NX_Q96M93

UniProt: Q96M93
Chr Location

4q27; chr4:122378966-122429802 (+) GRCh38

MGI Vertebrate Homology

Adad1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADAD1
Gene Tree

Adad1

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References

1 with disease annotations

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Phenotype Summary

9 phenotypes from 3 alleles in 4 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

2
Targeted

5
Genomic Mutations

2 involving Adad1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Nullizygous mutations of this gene result in male infertility and abnormal spermiogenesis. Male mice homozygous for a null allele have show reduced sperm counts and motility, and increased sperm malformation resulting in background-dependent sterility.

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All GO Annotations

14
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

783
Tissues

49
cDNA Data

12
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase adad1

ZFIN adad1

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All Sequences

38
RefSeq

2
UniProt

3
CCDS

CCDS17315.1

Ensembl

ENSMUSG00000027719 (Evidence)
NCBI Gene

21744

			Length	Strain/Species	Flank
genomic	21744	NCBI Gene Model \| MGI Sequence Detail	47857	C57BL/6J	± kb
transcript	NM_009350	RefSeq \| MGI Sequence Detail	1972	Not Specified
polypeptide	Q5SUE7	UniProt \| EBI \| MGI Sequence Detail	619	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003708 adenosine deaminase domain-containing protein 1

(term hierarchy)
InterPro Domains

IPR044455 ADAD1, double-stranded RNA binding domain

IPR002466 Adenosine deaminase/editase

IPR014720 Double-stranded RNA-binding domain

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All nucleic 14

cDNA 12

Primer pair 2

Microarray probesets 4

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MGD-MRK-24134

Summaries

All 40

Developmental Gene Expression 5

Diseases 1

Gene Ontology 5

Phenotypes 17
Earliest

J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Adad1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28884	Chr3:37116948-37116967 (+)	-847 bp
Tssr28885	Chr3:37117191-37117198 (+)	-610 bp
Tssr28886	Chr3:37117761-37117765 (+)	-42 bp
Tssr28887	Chr3:37117780-37117788 (+)	-21 bp
Tssr28888	Chr3:37117793-37117821 (+)	2 bp
Tssr28889	Chr3:37117823-37117846 (+)	30 bp
Tssr28890	Chr3:37117847-37117849 (+)	43 bp
Tssr28891	Chr3:37117853-37117864 (+)	54 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24