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Lpo Gene Detail
Summary
  • Symbol
    Lpo
  • Name
    lactoperoxidase
  • Synonyms
    5830499B15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923363
    NCBI Gene: 76113
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:87697254-87716750 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 52.22 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    187 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923363
 protein coding gene Chr11:87697254-87719115 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018913
 protein coding gene Chr11:89440107-89461665 (-)
A/J MGP_AJ_G0018880
 protein coding gene Chr11:85993137-86014368 (-)
AKR/J MGP_AKRJ_G0018850
 protein coding gene Chr11:88566949-88588455 (-)
BALB/cJ MGP_BALBcJ_G0018853
 protein coding gene Chr11:86394045-86416359 (-)
C3H/HeJ MGP_C3HHeJ_G0018667
 protein coding gene Chr11:88610047-88632431 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019305
 protein coding gene Chr11:92155800-92180812 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016938
 protein coding gene Chr11:83019864-83042836 (-)
CAST/EiJ MGP_CASTEiJ_G0018222
 protein coding gene Chr11:89306109-89329671 (-)
CBA/J MGP_CBAJ_G0018638
 protein coding gene Chr11:96032015-96058122 (-)
DBA/2J MGP_DBA2J_G0018746
 protein coding gene Chr11:85546420-85568606 (-)
FVB/NJ MGP_FVBNJ_G0018735
 protein coding gene Chr11:85052563-85073950 (-)
LP/J MGP_LPJ_G0018816
 protein coding gene Chr11:89932625-89953990 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018762
 protein coding gene Chr11:96064034-96087212 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019345
 protein coding gene Chr11:88805995-88832155 (-)
PWK/PhJ MGP_PWKPhJ_G0017992
 protein coding gene Chr11:86396377-86419107 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017785
 protein coding gene Chr11:88364860-88392588 (-)
WSB/EiJ MGP_WSBEiJ_G0018273
 protein coding gene Chr11:88698046-88720554 (-)



Homology
more
  • Human Ortholog
    LPO, lactoperoxidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LPO, lactoperoxidase
  • Synonyms
    SPO
  • Links
    NCBI Gene ID: 4025
    neXtProt AC: NX_P22079
    UniProt: P22079

  • Chr Location
    17q22; chr17:58218548-58268518 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit inflammation and lesions in the cardiovascular, respiratory, digestive, or excretory systems, neuropathology, and high incidence of tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    96
  • cDNA Data
    110
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76113 NCBI Gene Model | MGI Sequence Detail 19497 C57BL/6J ±  kb
    transcript NM_080420 RefSeq | MGI Sequence Detail 2595 C57BL/6  
    polypeptide Q5SW46 UniProt | EBI | MGI Sequence Detail 710 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 112
      cDNA 110
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 9
      Phenotypes 21
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory