Thoc6 MGI Mouse Gene Detail - MGI:2677480

Symbol

Thoc6
Name

THO complex 6
Synonyms

F830014G06Rik, Wdr58

Feature Type

protein coding gene
IDs

MGI:2677480
NCBI Gene: 386612
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr17:23887588-23892856 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 11.97 cM
Mapping Data

1 experiment

SNPs within 2kb

133 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2677480	protein coding gene	Chr17:23887588-23892891 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023261	protein coding gene	Chr17:22582519-22589257 (-)
A/J	MGP_AJ_G0023221	protein coding gene	Chr17:21933345-21939512 (-)
AKR/J	MGP_AKRJ_G0023191	protein coding gene	Chr17:22010617-22015850 (-)
BALB/cJ	MGP_BALBcJ_G0023226	protein coding gene	Chr17:22148648-22153944 (-)
C3H/HeJ	MGP_C3HHeJ_G0022986	protein coding gene	Chr17:22371419-22377354 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023669	protein coding gene	Chr17:23564480-23570755 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021150	protein coding gene	Chr17:19503519-19508546 (-)
CAST/EiJ	MGP_CASTEiJ_G0022492	protein coding gene	Chr17:22205133-22210205 (-)
CBA/J	MGP_CBAJ_G0022962	protein coding gene	Chr17:24375998-24381131 (-)
DBA/2J	MGP_DBA2J_G0023094	protein coding gene	Chr17:21562689-21567810 (-)
FVB/NJ	MGP_FVBNJ_G0023061	protein coding gene	Chr17:21287437-21292462 (-)
LP/J	MGP_LPJ_G0023168	protein coding gene	Chr17:22842198-22847335 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023080	protein coding gene	Chr17:24138541-24143637 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023708	protein coding gene	Chr17:22302539-22309130 (-)
PWK/PhJ	MGP_PWKPhJ_G0022240	protein coding gene	Chr17:20347548-20352864 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022060	protein coding gene	Chr17:20327844-20332985 (-)
WSB/EiJ	MGP_WSBEiJ_G0022555	protein coding gene	Chr17:22358201-22364318 (-)

Human Ortholog

THOC6, THO complex subunit 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

THOC6, THO complex subunit 6
Synonyms

fSAP35, MMRFCGU, WDR58
Links

HGNC:28369

NCBI Gene ID: 79228

neXtProt AC: NX_Q86W42

UniProt: Q86W42
Chr Location

16p13.3; chr16:3024027-3027755 (+) GRCh38

MGI Vertebrate Homology

Thoc6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: THOC6
Gene Tree

Thoc6

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Gene trapped

3
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice with biallelic loss of function are embryonic lethal by E11.5. Embryos are smaller, show developmental delay by E9.5, and show thinner epithelium in the telencephalic vesicles.

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All GO Annotations

24
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

46
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase thoc6

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All Sequences

48
RefSeq

6
UniProt

2
CCDS

CCDS28454.1

Ensembl

ENSMUSG00000041319 (Evidence)
NCBI Gene

386612

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041319	Ensembl Gene Model \| MGI Sequence Detail	5269	C57BL/6J	± kb
transcript	ENSMUST00000115490	Ensembl \| MGI Sequence Detail	1431	Not Applicable
polypeptide	ENSMUSP00000111153	Ensembl \| MGI Sequence Detail	341	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016315 THO complex subunit 6

(term hierarchy)
InterPro Domains

IPR042626 THO complex subunit 6

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 46

cDNA 46

Microarray probesets 3

Summaries

All 32

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Thoc6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146637	Chr17:23894033-23894078 (-)	-1,200 bp
Tssr146636	Chr17:23892799-23892861 (-)	26 bp
Tssr146635	Chr17:23892531-23892551 (-)	315 bp
Tssr146634	Chr17:23889917-23889918 (-)	2,938 bp
Tssr146633	Chr17:23889898-23889915 (-)	2,949 bp
Tssr146632	Chr17:23889864-23889887 (-)	2,980 bp
Tssr146631	Chr17:23889837-23889847 (-)	3,014 bp
Tssr146630	Chr17:23889759-23889766 (-)	3,093 bp
Tssr5030	Chr17:23888983-23888984 (-)	3,872 bp
Tssr146629	Chr17:23888943-23888978 (-)	3,895 bp
Tssr146628	Chr17:23888920-23888941 (-)	3,925 bp
Tssr146627	Chr17:23888895-23888912 (-)	3,952 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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