About   Help   FAQ
Dync2i2 Gene Detail
Summary
  • Symbol
    Dync2i2
  • Name
    dynein 2 intermediate chain 2
  • Synonyms
    3200002I06Rik, Wdr34
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919070
    NCBI Gene: 71820
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:29921563-29938891 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 21.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    506 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919070
 protein coding gene Chr2:29921558-29938893 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025550
 protein coding gene Chr2:28225436-28242738 (-)
A/J MGP_AJ_G0025528
 protein coding gene Chr2:27106467-27123756 (-)
AKR/J MGP_AKRJ_G0025497
 protein coding gene Chr2:28028981-28046298 (-)
BALB/cJ MGP_BALBcJ_G0025523
 protein coding gene Chr2:27236836-27254927 (-)
C3H/HeJ MGP_C3HHeJ_G0025285
 protein coding gene Chr2:27955599-27972920 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025968
 protein coding gene Chr2:29131496-29151697 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023377
 protein coding gene Chr2:25901948-25919982 (-)
CAST/EiJ MGP_CASTEiJ_G0024748
 protein coding gene Chr2:27840494-27857628 (-)
CBA/J MGP_CBAJ_G0025262
 protein coding gene Chr2:30133974-30159656 (-)
DBA/2J MGP_DBA2J_G0025395
 protein coding gene Chr2:26901460-26918795 (-)
FVB/NJ MGP_FVBNJ_G0025358
 protein coding gene Chr2:26707840-26726763 (-)
LP/J MGP_LPJ_G0025481
 protein coding gene Chr2:28139801-28159210 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025388
 protein coding gene Chr2:30057554-30077564 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026027
 protein coding gene Chr2:27950126-27968479 (-)
PWK/PhJ MGP_PWKPhJ_G0024494
 protein coding gene Chr2:26731979-26750060 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024294
 protein coding gene Chr2:28022996-28042019 (-)
WSB/EiJ MGP_WSBEiJ_G0024816
 protein coding gene Chr2:28063068-28080516 (-)



Homology
more
  • Human Ortholog
    DYNC2I2, dynein 2 intermediate chain 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DYNC2I2, dynein 2 intermediate chain 2
  • Synonyms
    bA216B9.3, CFAP133, DIC5, FAP133, SRTD11, WDR34
  • Links
    NCBI Gene ID: 89891
    neXtProt AC: NX_Q96EX3
    UniProt: Q96EX3

  • Chr Location
    9q34.11; chr9:128633653-128684460 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DYNC2I2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit midgestational lethality, embryonic growth retardation, open brain and neural tube, microphthalmia, wider limb paddles, polydactyly, defects in retrograde ciliary protein trafficking and Hedgehog signaling, and stumpy cilia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    28
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71820 NCBI Gene Model | MGI Sequence Detail 17329 C57BL/6J ±  kb
    transcript NM_001008498 RefSeq | MGI Sequence Detail 1812 C57BL/6  
    polypeptide Q5U4F6 UniProt | EBI | MGI Sequence Detail 537 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 28

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:6458744
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:335806 Yan L, et al., Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos. Front Cell Dev Biol. 2023;11:1084245
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory