Lmtk3 MGI Mouse Gene Detail - MGI:3039582

Symbol

Lmtk3
Name

lemur tyrosine kinase 3
Synonyms

Aatyk3, AATYK3

Feature Type

protein coding gene
IDs

MGI:3039582
NCBI Gene: 381983
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:45433162-45453568 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.50 cM
Mapping Data

1 experiment

SNPs within 2kb

526 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3039582	protein coding gene	Chr7:45432577-45456315 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032247	protein coding gene	Chr7:46103124-46125331 (+)
A/J	MGP_AJ_G0032226	protein coding gene	Chr7:45181919-45203030 (+)
AKR/J	MGP_AKRJ_G0032162	protein coding gene	Chr7:46449996-46473218 (+)
BALB/cJ	MGP_BALBcJ_G0032238	protein coding gene	Chr7:45180560-45201026 (+)
C3H/HeJ	MGP_C3HHeJ_G0031953	protein coding gene	Chr7:46932280-46955895 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032730	protein coding gene	Chr7:48364865-48385261 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029744	protein coding gene	Chr7:47732904-47753350 (+)
CAST/EiJ	MGP_CASTEiJ_G0031281	protein coding gene	Chr7:38374971-38404180 (+)
CBA/J	MGP_CBAJ_G0031918	protein coding gene	Chr7:49987663-50008057 (+)
DBA/2J	MGP_DBA2J_G0032076	protein coding gene	Chr7:44860951-44881327 (+)
FVB/NJ	MGP_FVBNJ_G0032027	protein coding gene	Chr7:44636988-44657542 (+)
LP/J	MGP_LPJ_G0032154	protein coding gene	Chr7:46807008-46829308 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032064	protein coding gene	Chr7:48649210-48674261 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032746	protein coding gene	Chr7:45656428-45678979 (+)
PWK/PhJ	MGP_PWKPhJ_G0031004	protein coding gene	Chr7:38232322-38255705 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030842	protein coding gene	Chr7:33684725-33709322 (+)
WSB/EiJ	MGP_WSBEiJ_G0031399	protein coding gene	Chr7:46154296-46174745 (+)

Human Ortholog

LMTK3, lemur tyrosine kinase 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LMTK3, lemur tyrosine kinase 3
Synonyms

AATYK3, LMR3, PPP1R101, TYKLM3
Links

HGNC:19295

NCBI Gene ID: 114783

UniProt: Q96Q04
Chr Location

19q13.33; chr19:48485271-48513935 (-) GRCh38

MGI Vertebrate Homology

Lmtk3 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: LMTK3
Gene Tree

Lmtk3

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Phenotype Summary

16 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit pronounced behavioral abnormalities, including locomotor hyperactivity, reduced anxiety, and decreased depression-like behavior, an increased striatal dopamine turnover rate, and enhanced behavioral response to methylphenidate.

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All GO Annotations

10
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

787
Tissues

15
cDNA Data

7
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lmtk3

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All Sequences

74
RefSeq

20
UniProt

8
CCDS

CCDS39961.1

Ensembl

ENSMUSG00000062044 (Evidence)
NCBI Gene

381983

			Length	Strain/Species	Flank
genomic	ENSMUSG00000062044	Ensembl Gene Model \| MGI Sequence Detail	20407	C57BL/6J	± kb
transcript	ENSMUST00000209617	Ensembl \| MGI Sequence Detail	5051	Not Applicable
polypeptide	ENSMUSP00000148041	Ensembl \| MGI Sequence Detail	1450	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000009869 serine/threonine-protein kinase LMTK3

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR008266 Tyrosine-protein kinase, active site
GlyGen

Q5XJV6 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 7

cDNA 7

Microarray probesets 4

Summaries

All 31

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 6
Earliest

J:128285 Tomomura M, et al., Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family. Neuroscience. 2007 Aug 24;148(2):510-21
Latest

J:282854 Montrose K, et al., Lmtk3-KO Mice Display a Range of Behavioral Abnormalities and Have an Impairment in GluA1 Trafficking. Neuroscience. 2019 Aug 21;414:154-167

TSS for Lmtk3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr66636	Chr7:45433110-45433156 (+)	-29 bp
Tssr66637	Chr7:45433307-45433368 (+)	176 bp
Tssr66638	Chr7:45434755-45434814 (+)	1,623 bp
Tssr66639	Chr7:45434994-45435031 (+)	1,851 bp
Tssr66640	Chr7:45436812-45436852 (+)	3,670 bp
Tssr66641	Chr7:45450108-45450152 (+)	16,968 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24