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Clpb Gene Detail
Summary
  • Symbol
    Clpb
  • Name
    ClpB caseinolytic peptidase B
  • Synonyms
    Skd3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100517
    NCBI Gene: 20480
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:101312958-101444667 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.63 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2719 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100517
 protein coding gene Chr7:101312840-101444713 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032586
 protein coding gene Chr7:104669135-104798524 (+)
A/J MGP_AJ_G0032562
 protein coding gene Chr7:102002818-102130824 (+)
AKR/J MGP_AKRJ_G0032498
 protein coding gene Chr7:104444924-104577115 (+)
BALB/cJ MGP_BALBcJ_G0032573
 protein coding gene Chr7:101701583-101828177 (+)
C3H/HeJ MGP_C3HHeJ_G0032287
 protein coding gene Chr7:104822052-104949821 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033070
 protein coding gene Chr7:108604533-108733467 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030064
 protein coding gene Chr7:104359636-104486915 (+)
CAST/EiJ MGP_CASTEiJ_G0031613
 protein coding gene Chr7:96368233-96497144 (+)
CBA/J MGP_CBAJ_G0032253
 protein coding gene Chr7:112376779-112507874 (+)
DBA/2J MGP_DBA2J_G0032405
 protein coding gene Chr7:100333853-100461469 (+)
FVB/NJ MGP_FVBNJ_G0032361
 protein coding gene Chr7:100108907-100239226 (+)
LP/J MGP_LPJ_G0032494
 protein coding gene Chr7:105984133-106112888 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032395
 protein coding gene Chr7:113717470-113848293 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033092
 protein coding gene Chr7:103710886-103838462 (+)
PWK/PhJ MGP_PWKPhJ_G0031331
 protein coding gene Chr7:93442161-93569762 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031175
 protein coding gene Chr7:90987439-91116937 (+)
WSB/EiJ MGP_WSBEiJ_G0031730
 protein coding gene Chr7:104399686-104528785 (+)



Homology
more
  • Human Ortholog
    CLPB, ClpB family mitochondrial disaggregase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLPB, ClpB family mitochondrial disaggregase
  • Synonyms
    ANKCLB, ANKCLP, HSP78, MEGCANN, MGCA7, MGCA7A, SCN9, SKD3
  • Links
    NCBI Gene ID: 81570
    neXtProt AC: NX_Q9H078
    UniProt: Q9H078

  • Chr Location
    11q13.4; chr11:72285495-72434680 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CLPB associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    22
  • cDNA Data
    109
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20480 NCBI Gene Model | MGI Sequence Detail 131710 C57BL/6J ±  kb
transcript NR_184442 RefSeq | MGI Sequence Detail 4693 C57BL/6  
polypeptide Q60649 UniProt | EBI | MGI Sequence Detail 677 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 113
    cDNA 113

    Microarray probesets 6
Other
Accession IDs
less
MGI:3034703
References
more
  • Summaries
    All 48
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 16
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory