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Slc30a1 Gene Detail
Summary
  • Symbol
    Slc30a1
  • Name
    solute carrier family 30 (zinc transporter), member 1
  • Synonyms
    C130040I11Rik, Znt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345281
    NCBI Gene: 22782
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:191638879-191645359 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 97.01 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345281
 protein coding gene Chr1:191638810-191645359 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016949
 protein coding gene Chr1:198986257-198992734 (+)
A/J MGP_AJ_G0016928
 protein coding gene Chr1:190818135-190824610 (+)
AKR/J MGP_AKRJ_G0016893
 protein coding gene Chr1:196492906-196499386 (+)
BALB/cJ MGP_BALBcJ_G0016886
 protein coding gene Chr1:191497425-191503903 (+)
C3H/HeJ MGP_C3HHeJ_G0016710
 protein coding gene Chr1:197332892-197339398 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017349
 protein coding gene Chr1:205332067-205338544 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015056
 protein coding gene Chr1:181716423-181722864 (+)
CAST/EiJ MGP_CASTEiJ_G0016293
 protein coding gene Chr1:196930340-196936810 (+)
CBA/J MGP_CBAJ_G0016684
 protein coding gene Chr1:212943866-212950341 (+)
DBA/2J MGP_DBA2J_G0016790
 protein coding gene Chr1:189541437-189547915 (+)
FVB/NJ MGP_FVBNJ_G0016786
 protein coding gene Chr1:187666572-187673050 (+)
LP/J MGP_LPJ_G0016865
 protein coding gene Chr1:200173724-200180201 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016818
 protein coding gene Chr1:219590720-219597199 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017386
 protein coding gene Chr1:196363384-196369861 (+)
PWK/PhJ MGP_PWKPhJ_G0016080
 protein coding gene Chr1:188841398-188847876 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015856
 protein coding gene Chr1:195366456-195372911 (+)
WSB/EiJ MGP_WSBEiJ_G0016355
 protein coding gene Chr1:196607401-196613909 (+)



Homology
more
  • Human Ortholog
    SLC30A1, solute carrier family 30 member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC30A1, solute carrier family 30 member 1
  • Synonyms
    ZNT1, ZRC1
  • Links
    NCBI Gene ID: 7779
    neXtProt AC: NX_Q9Y6M5
    UniProt: Q9Y6M5

  • Chr Location
    1q32.3; chr1:211571568-211579161 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 images
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality soon after implantation with embryonic growth arrest at the egg cylinder stage. Embryos from heterozygous females on a zinc deficient diet develop abnormally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    910
  • Tissues
    103
  • cDNA Data
    37
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037434 Ensembl Gene Model | MGI Sequence Detail 6481 C57BL/6J ±  kb
    transcript ENSMUST00000044954 Ensembl | MGI Sequence Detail 5244 Not Applicable  
    polypeptide ENSMUSP00000042410 Ensembl | MGI Sequence Detail 503 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000015073 proton-coupled zinc antiporter SLC30A1
      (term hierarchy)
    • InterPro Domains
      IPR002524 Cation efflux protein
      IPR036837 Cation efflux protein, cytoplasmic domain superfamily
      IPR027469 Cation efflux transmembrane domain superfamily
    • GlyGen
      Q60738 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 1
      cDNA 37
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-24139, MGI:103261, MGI:2138330
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 4
    • Earliest
      J:23612 Palmiter RD, et al., Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc. EMBO J. 1995 Feb 15;14(4):639-49
    • Latest
      J:218025 Mellone M, et al., Zinc transporter-1: a novel NMDA receptor-binding protein at the postsynaptic density. J Neurochem. 2015 Jan;132(2):159-68
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory