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Irgm1 Gene Detail
Summary
  • Symbol
    Irgm1
  • Name
    immunity-related GTPase family M member 1
  • Synonyms
    Ifi1, Iigp3, Irgm, LRG-47
  • Feature Type
    protein coding gene
  • IDs
    MGI:107567
    NCBI Gene: 15944
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:48756072-48762247 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 28.84 cM, cytoband B1.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    101 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107567
 protein coding gene Chr11:48752795-48762510 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018207
 protein coding gene Chr11:47893178-47902866 (-)
A/J MGP_AJ_G0018178
 protein coding gene Chr11:45985939-45995684 (-)
AKR/J MGP_AKRJ_G0018144
 protein coding gene Chr11:47425432-47435137 (-)
BALB/cJ MGP_BALBcJ_G0018147
 protein coding gene Chr11:46201582-46211240 (-)
C3H/HeJ MGP_C3HHeJ_G0017961
 protein coding gene Chr11:47426895-47436520 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018601
 protein coding gene Chr11:49334616-49344765 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016256
 protein coding gene Chr11:43849980-43860111 (-)
CAST/EiJ MGP_CASTEiJ_G0017524
 protein coding gene Chr11:47589295-47601112 (-)
CBA/J MGP_CBAJ_G0017933
 protein coding gene Chr11:51598995-51609455 (-)
DBA/2J MGP_DBA2J_G0018043
 protein coding gene Chr11:45841706-45851351 (-)
FVB/NJ MGP_FVBNJ_G0018037
 protein coding gene Chr11:45433611-45443239 (-)
LP/J MGP_LPJ_G0018115
 protein coding gene Chr11:48140802-48150551 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018061
 protein coding gene Chr11:53049545-53060088 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018640
 protein coding gene Chr11:47582563-47592262 (-)
PWK/PhJ MGP_PWKPhJ_G0017304
 protein coding gene Chr11:46235132-46245289 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017097
 protein coding gene Chr11:47309458-47319615 (-)
WSB/EiJ MGP_WSBEiJ_G0017574
 protein coding gene Chr11:47212991-47222658 (-)



Homology
more
  • Human Ortholog
    IRGM, immunity related GTPase M
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRGM, immunity related GTPase M
  • Synonyms
    IBD19, IFI1, IRGM1, LRG-47, LRG47
  • Links
    NCBI Gene ID: 345611
    neXtProt AC: NX_A1A4Y4
    UniProt: A1A4Y4

  • Chr Location
    5q33.1; chr5:150846521-150902402 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human IRGM associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired cell-autonomous Toxoplasma killing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    93
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    798
  • Tissues
    45
  • cDNA Data
    64
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15944 NCBI Gene Model | MGI Sequence Detail 6176 C57BL/6J ±  kb
    transcript NM_008326 RefSeq | MGI Sequence Detail 2321 C57BL/6  
    polypeptide Q60766 UniProt | EBI | MGI Sequence Detail 409 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 65
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36139
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 2
      Gene Ontology 22
      Phenotypes 56
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory