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Cdkn2c Gene Detail
Summary
  • Symbol
    Cdkn2c
  • Name
    cyclin dependent kinase inhibitor 2C
  • Synonyms
    INK4c, p18, p18INK4c
  • Feature Type
    protein coding gene
  • IDs
    MGI:105388
    NCBI Gene: 12580
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:109518073-109523953 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 51.32 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    142 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105388
 protein coding gene Chr4:109518073-109524386 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028573
 protein coding gene Chr4:110431644-110437711 (-)
A/J MGP_AJ_G0028536
 protein coding gene Chr4:106457868-106464161 (-)
AKR/J MGP_AKRJ_G0028483
 protein coding gene Chr4:109121009-109127310 (-)
BALB/cJ MGP_BALBcJ_G0028555
 protein coding gene Chr4:106673410-106679700 (-)
C3H/HeJ MGP_C3HHeJ_G0028269
 protein coding gene Chr4:109873727-109880017 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028995
 protein coding gene Chr4:114417409-114423418 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026286
 protein coding gene Chr4:101751508-101757796 (-)
CAST/EiJ MGP_CASTEiJ_G0027705
 protein coding gene Chr4:107714206-107722079 (-)
CBA/J MGP_CBAJ_G0028238
 protein coding gene Chr4:118162464-118168717 (-)
DBA/2J MGP_DBA2J_G0028386
 protein coding gene Chr4:106084953-106091242 (-)
FVB/NJ MGP_FVBNJ_G0028354
 protein coding gene Chr4:104959826-104966386 (-)
LP/J MGP_LPJ_G0028487
 protein coding gene Chr4:110705223-110712769 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028380
 protein coding gene Chr4:123344110-123350069 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029031
 protein coding gene Chr4:109352075-109358388 (-)
PWK/PhJ MGP_PWKPhJ_G0027431
 protein coding gene Chr4:104375365-104381763 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027255
 protein coding gene Chr4:106737579-106743896 (-)
WSB/EiJ MGP_WSBEiJ_G0027786
 protein coding gene Chr4:109539009-109547151 (-)



Homology
more
  • Human Ortholog
    CDKN2C, cyclin dependent kinase inhibitor 2C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDKN2C, cyclin dependent kinase inhibitor 2C
  • Synonyms
    INK4C, p18, p18-INK4C
  • Links
    NCBI Gene ID: 1031
    neXtProt AC: NX_P42773
    UniProt: P42773

  • Chr Location
    1p32.3; chr1:50960745-50974634 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 2 alleles in 4 genetic backgrounds
    62 phenotypes from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit kidney and mammary gland cortical cysts, Leydig cell hyperplasia, reduced testosterone levels, late developing thymic lymphomas and pituitary tumors, gigantism, and organomegaly.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    947
  • Tissues
    157
  • cDNA Data
    42
  • Literature Summary
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12580 NCBI Gene Model | MGI Sequence Detail 5881 C57BL/6J ±  kb
    transcript NM_001301368 RefSeq | MGI Sequence Detail 2043 C57BL/6  
    polypeptide Q60772 UniProt | EBI | MGI Sequence Detail 168 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 42
      Primer pair 6
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-33058, MGI:2140654
    References
    more
    • Summaries
      All 150
      Developmental Gene Expression 38
      Diseases 2
      Gene Ontology 4
      Phenotypes 73
    • Earliest
      J:24521 Hirai H, et al., Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol Cell Biol. 1995 May;15(5):2672-81
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory