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Naca Gene Detail
Summary
  • Symbol
    Naca
  • Name
    nascent polypeptide-associated complex alpha polypeptide
  • Synonyms
    LOC380777, mKIAA0363, skNAC
  • Feature Type
    protein coding gene
  • IDs
    MGI:106095
    NCBI Gene: 17938
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127871444-127884506 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 76.39 cM, cytoband D2-D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    313 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106095
 protein coding gene Chr10:127869144-127884506 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017845
 protein coding gene Chr10:131707609-131721938 (+)
A/J MGP_AJ_G0017820
 protein coding gene Chr10:126437241-126451453 (+)
AKR/J MGP_AKRJ_G0017783
 protein coding gene Chr10:130160227-130173582 (+)
BALB/cJ MGP_BALBcJ_G0017784
 protein coding gene Chr10:126822987-126836003 (+)
C3H/HeJ MGP_C3HHeJ_G0017607
 protein coding gene Chr10:130312522-130325543 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018239
 protein coding gene Chr10:136182525-136198521 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015917
 protein coding gene Chr10:120402276-120415758 (+)
CAST/EiJ MGP_CASTEiJ_G0017168
 protein coding gene Chr10:131023148-131037673 (+)
CBA/J MGP_CBAJ_G0017577
 protein coding gene Chr10:141701646-141714680 (+)
DBA/2J MGP_DBA2J_G0017683
 protein coding gene Chr10:125510247-125523530 (+)
FVB/NJ MGP_FVBNJ_G0017678
 protein coding gene Chr10:124447046-124460042 (+)
LP/J MGP_LPJ_G0017757
 protein coding gene Chr10:132323724-132336969 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017706
 protein coding gene Chr10:144306556-144321868 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018279
 protein coding gene Chr10:130252993-130266285 (+)
PWK/PhJ MGP_PWKPhJ_G0016953
 protein coding gene Chr10:125757488-125774928 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016742
 protein coding gene Chr10:129334784-129347772 (+)
WSB/EiJ MGP_WSBEiJ_G0017227
 protein coding gene Chr10:130468888-130482133 (+)



Homology
more
  • Human Ortholog
    NACA, nascent polypeptide associated complex subunit alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NACA, nascent polypeptide associated complex subunit alpha
  • Synonyms
    HSD48, NACA1, NAC-alpha, skNAC
  • Links
    NCBI Gene ID: 4666
    neXtProt AC: NX_Q13765
    UniProt: E9PAV3, Q13765

  • Chr Location
    12q13.3; chr12:56712305-56731628 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    3 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a point mutation exhibit decreased bone volume and bone formation associated with accelerated mineralization and immature woven-bone formation. Mice null for the muscle specific isoform die during organogenesis with cardiac abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    784
  • Tissues
    34
  • cDNA Data
    280
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061315 Ensembl Gene Model | MGI Sequence Detail 13063 C57BL/6J ±  kb
    transcript ENSMUST00000092048 Ensembl | MGI Sequence Detail 6745 Not Applicable  
    polypeptide ENSMUSP00000089680 Ensembl | MGI Sequence Detail 2187 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000010950 nascent polypeptide-associated complex subunit alpha, muscle-specific form
      (term hierarchy)
    • InterPro Domains
      IPR038187 NAC A/B domain superfamily
      IPR002715 Nascent polypeptide-associated complex NAC domain
      IPR016641 Nascent polypeptide-associated complex subunit alpha-like
      IPR044034 Nascent polypeptide-associated complex subunit alpha-like, UBA domain
    • GlyGen
      P70670 49 sites, 1 O-linked glycan (49 sites)
    Molecular
    Reagents
    less
    • All nucleic 291
      Genomic 3
      cDNA 280
      Primer pair 7
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-33781, MGI:2144923, MGI:3037736
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:32006 Yotov WV, et al., Fine mapping of the alpha-NAC gene (Naca) to the distal end (D2-D3) of mouse chromosome 10. Mamm Genome. 1996 Mar;7(3):240
    • Latest
      J:318852 St-Arnaud R, et al., NACA and LRP6 Are Part of a Common Genetic Pathway Necessary for Full Anabolic Response to Intermittent PTH. Int J Mol Sci. 2022 Jan 15;23(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory