About   Help   FAQ
Stip1 Gene Detail
Summary
  • Symbol
    Stip1
  • Name
    stress-induced phosphoprotein 1
  • Synonyms
    Hop, Hsp70/Hsp90 organizing protein, IEF SSP 3521, p60, STI1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109130
    NCBI Gene: 20867
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6998070-7017335 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    536 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109130
 protein coding gene Chr19:6998064-7017394 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024782
 protein coding gene Chr19:4127258-4150181 (-)
A/J MGP_AJ_G0024749
 protein coding gene Chr19:3786783-3806466 (-)
AKR/J MGP_AKRJ_G0024722
 protein coding gene Chr19:3913421-3935701 (-)
BALB/cJ MGP_BALBcJ_G0024749
 protein coding gene Chr19:3896212-3918357 (-)
C3H/HeJ MGP_C3HHeJ_G0024517
 protein coding gene Chr19:4032799-4058389 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025195
 protein coding gene Chr19:4213355-4235750 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022629
 protein coding gene Chr19:3688781-3707622 (-)
CAST/EiJ MGP_CASTEiJ_G0023989
 protein coding gene Chr19:3942482-3962260 (-)
CBA/J MGP_CBAJ_G0024489
 protein coding gene Chr19:4275128-4302011 (-)
DBA/2J MGP_DBA2J_G0024616
 protein coding gene Chr19:3756703-3776093 (-)
FVB/NJ MGP_FVBNJ_G0024581
 protein coding gene Chr19:3786478-3805930 (-)
LP/J MGP_LPJ_G0024702
 protein coding gene Chr19:3984513-4008348 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024611
 protein coding gene Chr19:4179169-4198538 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025243
 protein coding gene Chr19:4049379-4069866 (-)
PWK/PhJ MGP_PWKPhJ_G0023735
 protein coding gene Chr19:3801085-3821419 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023539
 protein coding gene Chr19:3860484-3883988 (-)
WSB/EiJ MGP_WSBEiJ_G0024051
 protein coding gene Chr19:3953310-3975945 (-)



Homology
more
  • Human Ortholog
    STIP1, stress induced phosphoprotein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STIP1, stress induced phosphoprotein 1
  • Synonyms
    HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L
  • Links
    NCBI Gene ID: 10963
    neXtProt AC: NX_P31948
    UniProt: P31948

  • Chr Location
    11q13.1; chr11:64185272-64204543 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit embryonic lethality by E10.5, actute inflammation in the placental labyrinth, poorly formed neural tube and limb buds and increase double-strand breaks. Mice heterozygous for this allele exhibit susceptibility to ischemic brain injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    798
  • Tissues
    59
  • cDNA Data
    335
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024966 Ensembl Gene Model | MGI Sequence Detail 19266 C57BL/6J ±  kb
    transcript ENSMUST00000025918 Ensembl | MGI Sequence Detail 2108 Not Applicable  
    polypeptide ENSMUSP00000025918 Ensembl | MGI Sequence Detail 543 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 336
      cDNA 336

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38174
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:34088 Gross M, et al., Extensive sequencing of tryptic peptides of a rabbit reticulocyte 66-kDa protein that promotes recycling of Hsp 70. Homology To stress-related proteins. J Biol Chem. 1996 Jul 12;271(28):16842-9
    • Latest
      J:354599 Lackie RE, et al., Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of alpha-synuclein in vivo. Acta Neuropathol. 2022 Nov;144(5):881-910
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory