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Papss1 Gene Detail
Summary
  • Symbol
    Papss1
  • Name
    3'-phosphoadenosine 5'-phosphosulfate synthase 1
  • Synonyms
    Asapk, SK1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330587
    NCBI Gene: 23971
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:131270626-131349432 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 61.05 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2714 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330587
 protein coding gene Chr3:131270529-131349432 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027889
 protein coding gene Chr3:134292101-134373861 (+)
A/J MGP_AJ_G0027847
 protein coding gene Chr3:129551406-129631184 (+)
AKR/J MGP_AKRJ_G0027812
 protein coding gene Chr3:132925561-133007041 (+)
BALB/cJ MGP_BALBcJ_G0027860
 protein coding gene Chr3:129405986-129482264 (+)
C3H/HeJ MGP_C3HHeJ_G0027589
 protein coding gene Chr3:133330359-133418134 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028303
 protein coding gene Chr3:139012066-139098802 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025641
 protein coding gene Chr3:125060961-125139075 (+)
CAST/EiJ MGP_CASTEiJ_G0027045
 protein coding gene Chr3:132972404-133135854 (+)
CBA/J MGP_CBAJ_G0027565
 protein coding gene Chr3:143688785-143782126 (+)
DBA/2J MGP_DBA2J_G0027705
 protein coding gene Chr3:128750285-128829823 (+)
FVB/NJ MGP_FVBNJ_G0027672
 protein coding gene Chr3:126336378-126414539 (+)
LP/J MGP_LPJ_G0027815
 protein coding gene Chr3:135761044-135843293 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027703
 protein coding gene Chr3:151604734-151686373 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028361
 protein coding gene Chr3:132619325-132699121 (+)
PWK/PhJ MGP_PWKPhJ_G0026769
 protein coding gene Chr3:128494364-128573587 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026594
 protein coding gene Chr3:130674624-130760701 (+)
WSB/EiJ MGP_WSBEiJ_G0027124
 protein coding gene Chr3:133352974-133432800 (+)



Homology
more
  • Human Ortholog
    PAPSS1, 3'-phosphoadenosine 5'-phosphosulfate synthase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAPSS1, 3'-phosphoadenosine 5'-phosphosulfate synthase 1
  • Synonyms
    ATPSK1, PAPSS, SK1
  • Links
    NCBI Gene ID: 9061
    neXtProt AC: NX_O43252
    UniProt: O43252

  • Chr Location
    4q25; chr4:107590276-107720234 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    100
  • cDNA Data
    213
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 23971 NCBI Gene Model | MGI Sequence Detail 78807 C57BL/6J ±  kb
transcript NM_001410579 RefSeq | MGI Sequence Detail 3206 ZRU/MplStud  
polypeptide Q60967 UniProt | EBI | MGI Sequence Detail 624 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000012273 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
    (term hierarchy)
  • EC
    2.7.1.25, 2.7.7.4
  • InterPro Domains
    IPR002891 Adenylyl-sulfate kinase
    IPR025980 ATP-sulfurylase PUA-like domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR015947 PUA-like superfamily
    IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
    IPR002650 Sulphate adenylyltransferase
    IPR024951 Sulphate adenylyltransferase catalytic domain
  • GlyGen
    Q60967 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 216
    cDNA 213
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-28162, MGI:104865, MGI:2139680
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 10
    Phenotypes 7
  • Earliest
    J:30021 Li H, et al., The isolation and characterization of cDNA encoding the mouse bifunctional ATP sulfurylase-adenosine 5'-phosphosulfate kinase. J Biol Chem. 1995 Dec 8;270(49):29453-9
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory