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Pak3 Gene Detail
Summary
  • Symbol
    Pak3
  • Name
    p21 (RAC1) activated kinase 3
  • Synonyms
    PAK-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339656
    NCBI Gene: 18481
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:142301587-142580792 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 64.50 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5904 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339656
 protein coding gene ChrX:142301370-142580792 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036155
 protein coding gene ChrX:141072232-141361859 (+)
A/J MGP_AJ_G0036132
 protein coding gene ChrX:140412113-140687644 (+)
AKR/J MGP_AKRJ_G0036058
 protein coding gene ChrX:144956789-145245114 (+)
BALB/cJ MGP_BALBcJ_G0036123
 protein coding gene ChrX:138635016-138921504 (+)
C3H/HeJ MGP_C3HHeJ_G0035831
 protein coding gene ChrX:141150435-141435508 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036646
 protein coding gene ChrX:145014220-145308036 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033470
 protein coding gene ChrX:131934602-132215545 (+)
CAST/EiJ MGP_CASTEiJ_G0035122
 protein coding gene ChrX:121845616-122131762 (+)
CBA/J MGP_CBAJ_G0035808
 protein coding gene ChrX:149593814-149877803 (+)
DBA/2J MGP_DBA2J_G0035966
 protein coding gene ChrX:139507947-139783897 (+)
FVB/NJ MGP_FVBNJ_G0035900
 protein coding gene ChrX:138704430-138979141 (+)
LP/J MGP_LPJ_G0036057
 protein coding gene ChrX:142019596-142304389 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035936
 protein coding gene ChrX:157273817-157588050 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036683
 protein coding gene ChrX:140383002-140657539 (+)
PWK/PhJ MGP_PWKPhJ_G0034816
 protein coding gene ChrX:118647512-118927589 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034641
 protein coding gene ChrX:122383372-122677605 (+)
WSB/EiJ MGP_WSBEiJ_G0035257
 protein coding gene ChrX:138729328-139018517 (+)



Homology
more
  • Human Ortholog
    PAK3, p21 (RAC1) activated kinase 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAK3, p21 (RAC1) activated kinase 3
  • Synonyms
    ARA, beta-PAK, bPAK, MRX30, MRX47, OPHN3, PAK-3, PAK3beta, XLID30
  • Links
    NCBI Gene ID: 5063
    neXtProt AC: NX_O75914
    UniProt: O75914

  • Chr Location
    Xq23; chrX:110944285-111227361 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pak3 mouse models; 1 with human PAK3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele display a selective impairment in hippocampal late-phase long-term potentiation, and deficits in learning and memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    836
  • Tissues
    95
  • cDNA Data
    8
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031284 Ensembl Gene Model | MGI Sequence Detail 279206 C57BL/6J ±  kb
    transcript ENSMUST00000033640 Ensembl | MGI Sequence Detail 8348 Not Applicable  
    polypeptide ENSMUSP00000033640 Ensembl | MGI Sequence Detail 559 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 1
      cDNA 12
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33717, MGI:106033
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 27
      Diseases 1
      Gene Ontology 15
      Phenotypes 13
    • Earliest
      J:29051 Bagrodia S, et al., Identification of a mouse p21Cdc42/Rac activated kinase [published erratum appears in J Biol Chem 1996 Jan 12;271(2):1250]. J Biol Chem. 1995 Sep 29;270(39):22731-7
    • Latest
      J:357470 Hu B, et al., PAK2 is necessary for myelination in the peripheral nervous system. Brain. 2024 May 3;147(5):1809-1821
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory