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Foxf1 Gene Detail
Summary
  • Symbol
    Foxf1
  • Name
    forkhead box F1
  • Synonyms
    Foxf1, Foxf1a, Freac-1, FREAC1, Hfh8, HFH-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347470
    NCBI Gene: 15227
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:121811125-121814883 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 70.31 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    90 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347470
 protein coding gene Chr8:121811100-121814883 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034207
 protein coding gene Chr8:124561767-124565525 (+)
A/J MGP_AJ_G0034187
 protein coding gene Chr8:119382117-119385875 (+)
AKR/J MGP_AKRJ_G0034114
 protein coding gene Chr8:122865949-122869707 (+)
BALB/cJ MGP_BALBcJ_G0034181
 protein coding gene Chr8:119598762-119602520 (+)
C3H/HeJ MGP_C3HHeJ_G0033892
 protein coding gene Chr8:123596587-123600345 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034701
 protein coding gene Chr8:128702223-128705981 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031643
 protein coding gene Chr8:112249568-112253345 (+)
CAST/EiJ MGP_CASTEiJ_G0033219
 protein coding gene Chr8:123610421-123614197 (+)
CBA/J MGP_CBAJ_G0033865
 protein coding gene Chr8:133431169-133434927 (+)
DBA/2J MGP_DBA2J_G0034021
 protein coding gene Chr8:118591178-118594936 (+)
FVB/NJ MGP_FVBNJ_G0033964
 protein coding gene Chr8:117679629-117683387 (+)
LP/J MGP_LPJ_G0034110
 protein coding gene Chr8:124687772-124691530 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034011
 protein coding gene Chr8:135738133-135741891 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034719
 protein coding gene Chr8:123047242-123051001 (+)
PWK/PhJ MGP_PWKPhJ_G0032921
 protein coding gene Chr8:118390668-118394434 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032761
 protein coding gene Chr8:121760218-121763999 (+)
WSB/EiJ MGP_WSBEiJ_G0033335
 protein coding gene Chr8:123797465-123801239 (+)



Homology
more
  • Human Ortholog
    FOXF1, forkhead box F1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXF1, forkhead box F1
  • Synonyms
    ACDMPV, FKHL5, FREAC1
  • Links
    NCBI Gene ID: 2294
    neXtProt AC: NX_Q12946
    UniProt: Q12946

  • Chr Location
    16q24.1; chr16:86510527-86515422 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Foxf1 mouse models; 1 with human FOXF1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 5 alleles in 6 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in mid-gestation lethality, defects in extraembryonic and lateral plate mesoderm differentiation, failure of embryo turning, absence of yolk sac and allantois vasculogenesis, retarded somite and posterior embryo development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1578
  • Tissues
    498
  • cDNA Data
    25
  • Literature Summary
    109
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042812 Ensembl Gene Model | MGI Sequence Detail 3759 C57BL/6J ±  kb
    transcript ENSMUST00000181504 Ensembl | MGI Sequence Detail 2415 Not Applicable  
    polypeptide ENSMUSP00000137662 Ensembl | MGI Sequence Detail 378 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 2
      cDNA 27
      Primer pair 14
      Other 15

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16693, MGI:2142552, MGI:99897
    References
    more
    • Summaries
      All 157
      Developmental Gene Expression 109
      Diseases 1
      Gene Ontology 16
      Phenotypes 32
    • Earliest
      J:20863 Clevidence DE, et al., Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A. 1993 May 1;90(9):3948-52
    • Latest
      J:354194 Oikonomakos I, et al., In vitro differentiation of mouse pluripotent stem cells into corticosteroid-producing adrenocortical cells. Stem Cell Reports. 2024 Sep 10;19(9):1289-1303
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory