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Lamb3 Gene Detail
Summary
  • Symbol
    Lamb3
  • Name
    laminin, beta 3
  • Synonyms
    nicein, 125kDa
  • Feature Type
    protein coding gene
  • IDs
    MGI:99915
    NCBI Gene: 16780
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:192976661-193026186 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 97.71 cM, cytoband H2-H6
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1416 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99915
 protein coding gene Chr1:192890007-193026186 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016961
 protein coding gene Chr1:200296460-200441270 (+)
A/J MGP_AJ_G0016940
 protein coding gene Chr1:192057449-192201156 (+)
AKR/J MGP_AKRJ_G0016905
 protein coding gene Chr1:197784518-197931719 (+)
BALB/cJ MGP_BALBcJ_G0016898
 protein coding gene Chr1:192754258-192891612 (+)
C3H/HeJ MGP_C3HHeJ_G0016722
 protein coding gene Chr1:198626339-198774690 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017361
 protein coding gene Chr1:206661786-206805529 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015068
 protein coding gene Chr1:182933919-183072740 (+)
CAST/EiJ MGP_CASTEiJ_G0016305
 protein coding gene Chr1:198206495-198350843 (+)
CBA/J MGP_CBAJ_G0016696
 protein coding gene Chr1:214295858-214449278 (+)
DBA/2J MGP_DBA2J_G0016802
 protein coding gene Chr1:190775927-190916095 (+)
FVB/NJ MGP_FVBNJ_G0016798
 protein coding gene Chr1:188900401-189041802 (+)
LP/J MGP_LPJ_G0016877
 protein coding gene Chr1:201474590-201620026 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016830
 protein coding gene Chr1:220931793-221093845 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017398
 protein coding gene Chr1:197602938-197748344 (+)
PWK/PhJ MGP_PWKPhJ_G0016092
 protein coding gene Chr1:190097897-190241517 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015868
 protein coding gene Chr1:196632008-196779457 (+)
WSB/EiJ MGP_WSBEiJ_G0016367
 protein coding gene Chr1:197892507-198039883 (+)



Homology
more
  • Human Ortholog
    LAMB3, laminin subunit beta 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAMB3, laminin subunit beta 3
  • Synonyms
    AI1A, BM600-125KDA, JEB1A, JEB1B, LAM5, LAMNB1
  • Links
    NCBI Gene ID: 3914
    neXtProt AC: NX_Q13751
    UniProt: Q13751

  • Chr Location
    1q32.2; chr1:209614870-209652425 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Lamb3 mouse models; 3 with human LAMB3 associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    3 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous intracisternal A particle sequence insertion exhibit blistering of the skin and mucosal surfaces with abnormal hemidesmosomes. Mutants die neonatally, usually without feeding.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    984
  • Tissues
    164
  • cDNA Data
    41
  • Literature Summary
    42
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16780 NCBI Gene Model | MGI Sequence Detail 49526 C57BL/6J ±  kb
    transcript NM_008484 RefSeq | MGI Sequence Detail 4055 ZRU/MplStud  
    polypeptide Q61087 UniProt | EBI | MGI Sequence Detail 1168 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 42
      Primer pair 8

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16713
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 42
      Diseases 2
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:17618 Aberdam D, et al., Assignment of mouse nicein genes to chromosomes 1 and 18. Mamm Genome. 1994 Apr;5(4):229-33
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory