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Fzd8 Gene Detail
Summary
  • Symbol
    Fzd8
  • Name
    frizzled class receptor 8
  • Synonyms
    Fz8, mFZ8
  • Feature Type
    protein coding gene
  • IDs
    MGI:108460
    NCBI Gene: 14370
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:9212856-9216201 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 4.91 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108460
 protein coding gene Chr18:9212163-9218136 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024138
 protein coding gene Chr18:6174385-6177730 (+)
A/J MGP_AJ_G0024100
 protein coding gene Chr18:6123663-6127010 (+)
AKR/J MGP_AKRJ_G0024067
 protein coding gene Chr18:6244873-6248220 (+)
BALB/cJ MGP_BALBcJ_G0024099
 protein coding gene Chr18:6069721-6073067 (+)
C3H/HeJ MGP_C3HHeJ_G0023866
 protein coding gene Chr18:6140813-6144159 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024544
 protein coding gene Chr18:6510879-6514224 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021983
 protein coding gene Chr18:5679968-5683312 (+)
CAST/EiJ MGP_CASTEiJ_G0023343
 protein coding gene Chr18:6126405-6129748 (+)
CBA/J MGP_CBAJ_G0023838
 protein coding gene Chr18:6478408-6481754 (+)
DBA/2J MGP_DBA2J_G0023967
 protein coding gene Chr18:5949055-5952400 (+)
FVB/NJ MGP_FVBNJ_G0023932
 protein coding gene Chr18:5939491-5942836 (+)
LP/J MGP_LPJ_G0024050
 protein coding gene Chr18:6195352-6198697 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023961
 protein coding gene Chr18:6677478-6680823 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024590
 protein coding gene Chr18:6125547-6128892 (+)
PWK/PhJ MGP_PWKPhJ_G0023088
 protein coding gene Chr18:6004289-6007632 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022899
 protein coding gene Chr18:6384167-6387510 (+)
WSB/EiJ MGP_WSBEiJ_G0023409
 protein coding gene Chr18:6083201-6086546 (+)



Homology
more
  • Human Ortholog
    FZD8, frizzled class receptor 8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FZD8, frizzled class receptor 8
  • Synonyms
    FZ-8, hFZ8
  • Links
    NCBI Gene ID: 8325
    neXtProt AC: NX_Q9H461
    UniProt: Q9H461

  • Chr Location
    10p11.21; chr10:35638247-35642296 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene does not appear to result in a phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1304
  • Tissues
    350
  • cDNA Data
    28
  • Literature Summary
    71
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14370 NCBI Gene Model | MGI Sequence Detail 3346 C57BL/6J ±  kb
    transcript NM_008058 RefSeq | MGI Sequence Detail 3346 Not Specified  
    polypeptide Q61091 UniProt | EBI | MGI Sequence Detail 685 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      Genomic 1
      cDNA 30
      Primer pair 17
      Other 6

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-37504
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 71
      Gene Ontology 26
      Phenotypes 12
    • Earliest
      J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory