About   Help   FAQ
Dpf2 Gene Detail
Summary
  • Symbol
    Dpf2
  • Name
    double PHD fingers 2
  • Synonyms
    2210010M07Rik, Baf45d, Req, requiem, ubi-d4
  • Feature Type
    protein coding gene
  • IDs
    MGI:109529
    NCBI Gene: 19708
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5946544-5962899 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.34 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    409 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109529
 protein coding gene Chr19:5946544-5963038 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024732
 protein coding gene Chr19:2902489-2923661 (-)
A/J MGP_AJ_G0024698
 protein coding gene Chr19:2740125-2757494 (-)
AKR/J MGP_AKRJ_G0024671
 protein coding gene Chr19:2823856-2842336 (-)
BALB/cJ MGP_BALBcJ_G0024698
 protein coding gene Chr19:2732612-2756435 (-)
C3H/HeJ MGP_C3HHeJ_G0024466
 protein coding gene Chr19:2843781-2859587 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025145
 protein coding gene Chr19:2964613-2984414 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022575
 protein coding gene Chr19:2649171-2664757 (-)
CAST/EiJ MGP_CASTEiJ_G0023938
 protein coding gene Chr19:2849341-2865792 (-)
CBA/J MGP_CBAJ_G0024438
 protein coding gene Chr19:3104686-3128289 (-)
DBA/2J MGP_DBA2J_G0024565
 protein coding gene Chr19:2733682-2752158 (-)
FVB/NJ MGP_FVBNJ_G0024531
 protein coding gene Chr19:2737590-2754743 (-)
LP/J MGP_LPJ_G0024651
 protein coding gene Chr19:2862844-2884005 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024561
 protein coding gene Chr19:2931606-2948465 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025193
 protein coding gene Chr19:2839006-2857447 (-)
PWK/PhJ MGP_PWKPhJ_G0023684
 protein coding gene Chr19:2760785-2776555 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023489
 protein coding gene Chr19:2829693-2845994 (-)
WSB/EiJ MGP_WSBEiJ_G0024000
 protein coding gene Chr19:2848353-2866267 (-)



Homology
more
  • Human Ortholog
    DPF2, double PHD fingers 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPF2, double PHD fingers 2
  • Synonyms
    CSS7, REQ, SMARCG2, ubi-d4, UBID4
  • Links
    NCBI Gene ID: 5977
    neXtProt AC: NX_Q92785
    UniProt: Q92785

  • Chr Location
    11q13.1; chr11:65333843-65354262 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DPF2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a floxed allele are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    988
  • Tissues
    263
  • cDNA Data
    27
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19708 NCBI Gene Model | MGI Sequence Detail 16356 C57BL/6J ±  kb
    transcript NM_001291078 RefSeq | MGI Sequence Detail 3356 ZRU/MplStud  
    polypeptide Q61103 UniProt | EBI | MGI Sequence Detail 391 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 28
      Primer pair 3
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-39528, MGI:1925740
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 15
      Gene Ontology 15
      Phenotypes 13
    • Earliest
      J:40256 Gabig TG, et al., Requiem: a novel zinc finger gene essential for apoptosis in myeloid cells. J Biol Chem. 1994 Nov 25;269(47):29515-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory