Ppp2r5e MGI Mouse Gene Detail - MGI:1349473 - protein phosphatase 2, regulatory subunit B', epsilon

Symbol

Ppp2r5e
Name

protein phosphatase 2, regulatory subunit B', epsilon
Synonyms

4633401M22Rik, B56beta, protein phosphatase 2A subunit beta

Feature Type

protein coding gene
IDs

MGI:1349473
NCBI Gene: 26932
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr12:75497655-75643019 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 32.75 cM, cytoband D1
Mapping Data

4 experiments

SNPs within 2kb

2739 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349473	protein coding gene	Chr12:75496237-75643064 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019848	protein coding gene	Chr12:75461656-75624046 (-)
A/J	MGP_AJ_G0019806	protein coding gene	Chr12:72642175-72793169 (-)
AKR/J	MGP_AKRJ_G0019781	protein coding gene	Chr12:74835203-74985317 (-)
BALB/cJ	MGP_BALBcJ_G0019785	protein coding gene	Chr12:73108907-73255609 (-)
C3H/HeJ	MGP_C3HHeJ_G0019591	protein coding gene	Chr12:75302757-75451530 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020237	protein coding gene	Chr12:77830276-77989655 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017855	protein coding gene	Chr12:69985269-70133634 (-)
CAST/EiJ	MGP_CASTEiJ_G0019142	protein coding gene	Chr12:70085625-70238601 (-)
CBA/J	MGP_CBAJ_G0019561	protein coding gene	Chr12:80815738-80981477 (-)
DBA/2J	MGP_DBA2J_G0019677	protein coding gene	Chr12:72507565-72653318 (-)
FVB/NJ	MGP_FVBNJ_G0019664	protein coding gene	Chr12:71329677-71476200 (-)
LP/J	MGP_LPJ_G0019749	protein coding gene	Chr12:75480839-75633003 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019703	protein coding gene	Chr12:83884669-84039529 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020273	protein coding gene	Chr12:74316592-74466936 (-)
PWK/PhJ	MGP_PWKPhJ_G0018908	protein coding gene	Chr12:66851612-66999284 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018702	protein coding gene	Chr12:68798120-68955366 (-)
WSB/EiJ	MGP_WSBEiJ_G0019194	protein coding gene	Chr12:74906401-75061534 (-)

Human Ortholog

PPP2R5E, protein phosphatase 2 regulatory subunit B'epsilon

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP2R5E, protein phosphatase 2 regulatory subunit B'epsilon
Synonyms

B56E, B56epsilon
Links

HGNC:9313

NCBI Gene ID: 5529

neXtProt AC: NX_Q16537

UniProt: Q16537
Chr Location

14q23.2; chr14:63371364-63543377 (-) GRCh38

MGI Vertebrate Homology

Ppp2r5e stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PPP2R5E
Protein SuperFamily

PP2A_B56
Gene Tree

Ppp2r5e

less

Phenotype Summary

15 phenotype references

All Mutations and Alleles

175
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

169
Targeted

2
Genomic Mutations

1 involving Ppp2r5e
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

115 strains or lines available

less

All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

727
Tissues

21
cDNA Data

18
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppp2r5e

ZFIN ppp2r5ea, ppp2r5eb

less

All Sequences

64
RefSeq

8
UniProt

5
CCDS

CCDS25983.1

Ensembl

ENSMUSG00000021051 (Evidence)
NCBI Gene

26932

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021051	Ensembl Gene Model \| MGI Sequence Detail	145365	C57BL/6J	± kb
transcript	ENSMUST00000021447	Ensembl \| MGI Sequence Detail	4810	Not Applicable
polypeptide	ENSMUSP00000021447	Ensembl \| MGI Sequence Detail	467	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000013147 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR002554 Protein phosphatase 2A, regulatory B subunit, B56
GlyGen

Q61151 1 site, 1 O-linked glycan (1 site)

less

All nucleic 21

cDNA 20

Primer pair 1

Microarray probesets 9

less

MGI:1913952, MGI:2144826

Summaries

All 46

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 15
Earliest

J:55804 Okamoto K, et al., p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A. Mol Cell Biol. 1996 Nov;16(11):6593-602
Latest

J:348684 Dyson JJ, et al., Growth arrest of PPP2R5C and PPP2R5D double knockout mice indicates a genetic interaction and conserved function for these PP2A B subunits. FASEB Bioadv. 2022 Apr;4(4):273-282

TSS for Ppp2r5e:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116689	Chr12:75642969-75643035 (-)	17 bp
Tssr116688	Chr12:75642954-75642968 (-)	58 bp
Tssr116687	Chr12:75642937-75642950 (-)	75 bp
Tssr116686	Chr12:75642882-75642887 (-)	134 bp
Tssr116685	Chr12:75636316-75636318 (-)	6,702 bp
Tssr116684	Chr12:75630206-75630210 (-)	12,811 bp
Tssr116683	Chr12:75596442-75596469 (-)	46,563 bp
Tssr116682	Chr12:75596417-75596435 (-)	46,593 bp
Tssr116681	Chr12:75596410-75596414 (-)	46,607 bp
Tssr116680	Chr12:75530142-75530146 (-)	112,875 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24