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Tssk1 Gene Detail
Summary
  • Symbol
    Tssk1
  • Name
    testis-specific serine kinase 1
  • Synonyms
    Stk22a, Tsk1, TSK-1, Tssk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347557
    NCBI Gene: 22114
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17712067-17713517 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.09 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347557
 protein coding gene Chr16:17712067-17715786 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022595
 protein coding gene Chr16:15081099-15084798 (+)
A/J MGP_AJ_G0022556
 protein coding gene Chr16:14329909-14333608 (+)
AKR/J MGP_AKRJ_G0022533
 protein coding gene Chr16:14889584-14893283 (+)
BALB/cJ MGP_BALBcJ_G0022559
 protein coding gene Chr16:14483033-14486732 (+)
C3H/HeJ MGP_C3HHeJ_G0022326
 protein coding gene Chr16:15036166-15039865 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023010
 protein coding gene Chr16:15323349-15327048 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020530
 protein coding gene Chr16:14388127-14391821 (+)
CAST/EiJ MGP_CASTEiJ_G0021854
 protein coding gene Chr16:14952693-14956392 (+)
CBA/J MGP_CBAJ_G0022297
 protein coding gene Chr16:15996743-16000442 (+)
DBA/2J MGP_DBA2J_G0022427
 protein coding gene Chr16:14242223-14245922 (+)
FVB/NJ MGP_FVBNJ_G0022403
 protein coding gene Chr16:14292206-14296025 (+)
LP/J MGP_LPJ_G0022494
 protein coding gene Chr16:14864515-14868214 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022424
 protein coding gene Chr16:15675664-15679363 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023021
 protein coding gene Chr16:14834974-14838673 (+)
PWK/PhJ MGP_PWKPhJ_G0021597
 protein coding gene Chr16:14501121-14504820 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021425
 protein coding gene Chr16:14804297-14807996 (+)
WSB/EiJ MGP_WSBEiJ_G0021901
 protein coding gene Chr16:14819348-14823047 (+)



Homology
more
  • Human Ortholog
    TSSK1A, testis specific serine kinase 1A (pseudogene)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSSK1A, testis specific serine kinase 1A (pseudogene)
  • Synonyms
    SPOGA1, STK22A, TSSK1, TSSK1AP, TSSK1b, TSSK7P
  • Links
    NCBI Gene ID: 23752

  • Chr Location
    22q11.21; chr22:19124874-19125887 (+)  GRCh38
  • Human Ortholog
    TSSK1B, testis specific serine kinase 1B
  • Synonyms
    FKSG81, SPOGA4, STK22D, TSK1, TSSK1
  • Links
    NCBI Gene ID: 83942
    neXtProt AC: NX_Q9BXA7
    UniProt: Q9BXA7

  • Chr Location
    5q22.2; chr5:113432553-113434989 (-)  GRCh38
Human Diseases
less
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    52 phenotype references
Male mice homozygous for a knock-out allele of Tssk1 and 2 are infertile due to arrested spermatogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    38
  • cDNA Data
    19
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 22114 NCBI Gene Model | MGI Sequence Detail 1451 C57BL/6J ±  kb
transcript NM_009435 RefSeq | MGI Sequence Detail 1466 ZRU/MplStud  
polypeptide Q61241 UniProt | EBI | MGI Sequence Detail 365 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    Genomic 14
    cDNA 19
    Primer pair 3
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16319, MGI:99541
References
more
  • Summaries
    All 94
    Developmental Gene Expression 7
    Diseases 4
    Gene Ontology 11
    Phenotypes 52
  • Earliest
    J:17004 Bielke W, et al., Characterization of a novel murine testis-specific serine/threonine kinase. Gene. 1994 Feb 25;139(2):235-9
  • Latest
    J:342617 Dali O, et al., Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure. Life Sci Alliance. 2024 Feb;7(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory