Six4 MGI Mouse Gene Detail - MGI:106034 - sine oculis-related homeobox 4

Symbol

Six4
Name

sine oculis-related homeobox 4
Synonyms

AREC3, TrexBF

Feature Type

protein coding gene
IDs

MGI:106034
NCBI Gene: 20474
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:73146383-73160201 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 30.36 cM
Mapping Data

1 experiment

SNPs within 2kb

364 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106034	protein coding gene	Chr12:73146383-73160230 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019833	protein coding gene	Chr12:72974619-72988461 (-)
A/J	MGP_AJ_G0019791	protein coding gene	Chr12:70256582-70270627 (-)
AKR/J	MGP_AKRJ_G0019766	protein coding gene	Chr12:72381836-72395683 (-)
BALB/cJ	MGP_BALBcJ_G0019771	protein coding gene	Chr12:70733920-70747794 (-)
C3H/HeJ	MGP_C3HHeJ_G0019576	protein coding gene	Chr12:72808389-72822263 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020223	protein coding gene	Chr12:75252859-75266706 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017841	protein coding gene	Chr12:67707021-67720750 (-)
CAST/EiJ	MGP_CASTEiJ_G0019128	protein coding gene	Chr12:67603186-67617589 (-)
CBA/J	MGP_CBAJ_G0019546	protein coding gene	Chr12:78107707-78121776 (-)
DBA/2J	MGP_DBA2J_G0019662	protein coding gene	Chr12:70147376-70161223 (-)
FVB/NJ	MGP_FVBNJ_G0019649	protein coding gene	Chr12:68999963-69013827 (-)
LP/J	MGP_LPJ_G0019734	protein coding gene	Chr12:73012006-73025846 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019688	protein coding gene	Chr12:81262738-81276570 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020258	protein coding gene	Chr12:71866594-71880441 (-)
PWK/PhJ	MGP_PWKPhJ_G0018893	protein coding gene	Chr12:64456834-64470948 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018688	protein coding gene	Chr12:66265406-66288198 (-)
WSB/EiJ	MGP_WSBEiJ_G0019179	protein coding gene	Chr12:72456789-72470693 (-)

Human Ortholog

SIX4, SIX homeobox 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SIX4, SIX homeobox 4
Synonyms

AREC3
Links

HGNC:10890

NCBI Gene ID: 51804

neXtProt AC: NX_Q9UIU6

UniProt: Q9UIU6
Chr Location

14q23.1; chr14:60709539-60724351 (-) GRCh38

MGI Vertebrate Homology

Six4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SIX4
Gene Tree

Six4

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
33 phenotypes from multigenic genotypes
31 phenotype references

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Targeted

2
Genomic Mutations

1 involving Six4
Incidental Mutations

APF
Find Mice (IMSR)

36 strains or lines available

Homozygotes for a targeted null mutation are viable, fertile, and exhibit no apparent abnormalities suggesting compensation by other Six family members.

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All GO Annotations

52
GO References

22

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

955
Tissues

230
cDNA Data

40
Literature Summary

39

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase six4

ZFIN six4a, six4b

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All Sequences

42
RefSeq

6
UniProt

2
CCDS

CCDS25974.1, CCDS88351.1

Ensembl

ENSMUSG00000034460 (Evidence)
NCBI Gene

20474

			Length	Strain/Species	Flank
genomic	20474	NCBI Gene Model \| MGI Sequence Detail	13819	C57BL/6J	± kb
transcript	NM_011382	RefSeq \| MGI Sequence Detail	6222	C57BL/6
polypeptide	Q61321	UniProt \| EBI \| MGI Sequence Detail	775	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014899 homeobox protein SIX4

(term hierarchy)
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR009057 Homeobox-like domain superfamily

IPR031701 Homeobox protein SIX1, N-terminal SD domain
GlyGen

Q61321 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 49

cDNA 41

Primer pair 4

Other 4

Microarray probesets 6

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MGD-MRK-33718, MGI:2144757

Summaries

All 90

Developmental Gene Expression 39

Gene Ontology 22

Phenotypes 31
Earliest

J:31713 Kawakami K, et al., Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development. Nucleic Acids Res. 1996 Jan 15;24(2):303-10
Latest

J:344102 Racedo SE, et al., Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals. Dev Biol. 2024 Feb;506:72-84

TSS for Six4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116644	Chr12:73160181-73160209 (-)	6 bp
Tssr116643	Chr12:73149320-73149324 (-)	10,879 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24