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Traf4 Gene Detail
Summary
  • Symbol
    Traf4
  • Name
    TNF receptor associated factor 4
  • Synonyms
    A530032M13Rik, CART1, msp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202880
    NCBI Gene: 22032
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:78049325-78056415 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 46.74 cM, cytoband B5-C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    130 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202880
 protein coding gene Chr11:78049249-78056415 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018764
 protein coding gene Chr11:79140169-79147259 (-)
A/J MGP_AJ_G0018730
 protein coding gene Chr11:76117290-76124380 (-)
AKR/J MGP_AKRJ_G0018700
 protein coding gene Chr11:78421449-78428539 (-)
BALB/cJ MGP_BALBcJ_G0018704
 protein coding gene Chr11:76526520-76533610 (-)
C3H/HeJ MGP_C3HHeJ_G0018517
 protein coding gene Chr11:78462669-78469759 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019155
 protein coding gene Chr11:81611005-81618856 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016790
 protein coding gene Chr11:73091280-73098177 (-)
CAST/EiJ MGP_CASTEiJ_G0018071
 protein coding gene Chr11:78900695-78907811 (-)
CBA/J MGP_CBAJ_G0018487
 protein coding gene Chr11:85171013-85178103 (-)
DBA/2J MGP_DBA2J_G0018596
 protein coding gene Chr11:75699331-75706421 (-)
FVB/NJ MGP_FVBNJ_G0018586
 protein coding gene Chr11:75286555-75293645 (-)
LP/J MGP_LPJ_G0018667
 protein coding gene Chr11:79675881-79682971 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018612
 protein coding gene Chr11:85596013-85603103 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019195
 protein coding gene Chr11:78665252-78672342 (-)
PWK/PhJ MGP_PWKPhJ_G0017842
 protein coding gene Chr11:76481125-76488220 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017633
 protein coding gene Chr11:78271554-78280300 (-)
WSB/EiJ MGP_WSBEiJ_G0018124
 protein coding gene Chr11:78478968-78486087 (-)



Homology
more
  • Human Ortholog
    TRAF4, TNF receptor associated factor 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRAF4, TNF receptor associated factor 4
  • Synonyms
    CART1, MLN62, RNF83
  • Links
    NCBI Gene ID: 9618
    neXtProt AC: NX_Q9BUZ4
    UniProt: Q9BUZ4

  • Chr Location
    17q11.2; chr17:28744011-28750956 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 3 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations show respiratory problems, various skeletal defects, spina bifida and partial lethality around embryonic day 14. Homozygotes for an ENU-induced mutation exhibit postnatal lethality and hypopigmentation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    881
  • Tissues
    160
  • cDNA Data
    135
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017386 Ensembl Gene Model | MGI Sequence Detail 7091 C57BL/6J ±  kb
    transcript ENSMUST00000017530 Ensembl | MGI Sequence Detail 2078 Not Applicable  
    polypeptide ENSMUSP00000017530 Ensembl | MGI Sequence Detail 470 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 139
      cDNA 137
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2443728, MGI:3807535
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 25
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:354870 Xiao J, et al., TRAF4 is crucial for ST2+ memory Th2 cell expansion in IL-33-driven airway inflammation. JCI Insight. 2023 Sep 22;8(18)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory