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Hras Gene Detail
Summary
  • Symbol
    Hras
  • Name
    Harvey rat sarcoma virus oncogene
  • Synonyms
    c-H-ras, c-rasHa, Ha-ras, Harvey-ras, H-ras, Hras-1, Hras1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96224
    NCBI Gene: 15461
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr7:140770839-140773938 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 86.48 cM
  • Mapping Data
    31 experiments
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96224
 protein coding gene Chr7:140769018-140773938 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033214
 protein coding gene Chr7:146365248-146370148 (-)
A/J MGP_AJ_G0033196
 protein coding gene Chr7:142179696-142184596 (-)
AKR/J MGP_AKRJ_G0033128
 protein coding gene Chr7:146098348-146103248 (-)
BALB/cJ MGP_BALBcJ_G0033197
 protein coding gene Chr7:141920427-141925327 (-)
C3H/HeJ MGP_C3HHeJ_G0032911
 protein coding gene Chr7:145855797-145860697 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033708
 protein coding gene Chr7:151717143-151722043 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030681
 protein coding gene Chr7:143389632-143394500 (-)
CAST/EiJ MGP_CASTEiJ_G0032241
 protein coding gene Chr7:138164508-138169389 (-)
CBA/J MGP_CBAJ_G0032883
 protein coding gene Chr7:156841323-156846223 (-)
DBA/2J MGP_DBA2J_G0033035
 protein coding gene Chr7:140127236-140132136 (-)
FVB/NJ MGP_FVBNJ_G0032988
 protein coding gene Chr7:140039978-140044878 (-)
LP/J MGP_LPJ_G0033130
 protein coding gene Chr7:147861594-147866494 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033021
 protein coding gene Chr7:157508623-157513523 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033728
 protein coding gene Chr7:145076822-145081722 (-)
PWK/PhJ MGP_PWKPhJ_G0031945
 protein coding gene Chr7:133407409-133412313 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031792
 protein coding gene Chr7:131901364-131907888 (-)
WSB/EiJ MGP_WSBEiJ_G0032352
 protein coding gene Chr7:146025039-146029939 (-)



Homology
more
  • Human Ortholog
    HRAS, HRas proto-oncogene, GTPase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HRAS, HRas proto-oncogene, GTPase
  • Synonyms
    C-BAS/HAS, C-HA-RAS1, C-H-RAS, CTLO, HAMSV, HRAS1, H-RASIDX, p21ras, RASH1
  • Links
    NCBI Gene ID: 3265
    neXtProt AC: NX_P01112
    UniProt: P01112

  • Chr Location
    11p15.5; chr11:532242-537321 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Hras mouse models; 16 with human HRAS associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    70 phenotypes from 9 alleles in 11 genetic backgrounds
    11 phenotypes from multigenic genotypes
    3 images
    93 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted null mutations are viable and fertile with no gross morphological or histological abnormalities, defects in neuronal development or defects in lymphocyte cell populations. A decreased susceptibility to DMBA induced skin papillomas was also demonstrated.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    119
  • GO References
    39
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    993
  • Tissues
    97
  • cDNA Data
    72
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15461 NCBI Gene Model | MGI Sequence Detail 3100 C57BL/6J ±  kb
    transcript NR_178205 RefSeq | MGI Sequence Detail 1285 ZRU/MplStud  
    polypeptide Q61411 UniProt | EBI | MGI Sequence Detail 189 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 90
      Genomic 9
      cDNA 72
      Primer pair 4
      Other 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10930, MGD-MRK-10931
    References
    more
    • Summaries
      All 354
      Developmental Gene Expression 26
      Diseases 5
      Gene Ontology 39
      Phenotypes 93
    • Earliest
      J:6408 Shih TY, et al., Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus. Nature. 1980 Oct 23;287(5784):686-91
    • Latest
      J:354289 Holl D, et al., Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice. Nat Neurosci. 2024 Jul;27(7):1285-1298
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory