Cd37 MGI Mouse Gene Detail - MGI:88330

Symbol

Cd37
Name

CD37 antigen
Synonyms

Tspan26

Feature Type

protein coding gene
IDs

MGI:88330
NCBI Gene: 12493
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr7:44883056-44888539 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.20 cM
Mapping Data

4 experiments

SNPs within 2kb

207 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88330	protein coding gene	Chr7:44883056-44888701 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032211	protein coding gene	Chr7:45476868-45482353 (-)
A/J	MGP_AJ_G0032190	protein coding gene	Chr7:44608062-44613583 (-)
AKR/J	MGP_AKRJ_G0032126	protein coding gene	Chr7:45838795-45844261 (-)
BALB/cJ	MGP_BALBcJ_G0032202	protein coding gene	Chr7:44607712-44613221 (-)
C3H/HeJ	MGP_C3HHeJ_G0031918	protein coding gene	Chr7:46331231-46336713 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032694	protein coding gene	Chr7:47741892-47747363 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029708	protein coding gene	Chr7:47170910-47176425 (-)
CAST/EiJ	MGP_CASTEiJ_G0031246	protein coding gene	Chr7:37730153-37735666 (-)
CBA/J	MGP_CBAJ_G0031882	protein coding gene	Chr7:49312044-49317514 (-)
DBA/2J	MGP_DBA2J_G0032040	protein coding gene	Chr7:44281498-44287014 (-)
FVB/NJ	MGP_FVBNJ_G0031991	protein coding gene	Chr7:44057092-44062557 (-)
LP/J	MGP_LPJ_G0032118	protein coding gene	Chr7:46159247-46164743 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032028	protein coding gene	Chr7:48021681-48027164 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032710	protein coding gene	Chr7:45059778-45065313 (-)
PWK/PhJ	MGP_PWKPhJ_G0030969	protein coding gene	Chr7:37647383-37653145 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030806	protein coding gene	Chr7:33072416-33079194 (-)
WSB/EiJ	MGP_WSBEiJ_G0031363	protein coding gene	Chr7:45552796-45558308 (-)

Human Ortholog

CD37, CD37 molecule

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD37, CD37 molecule
Synonyms

GP52-40, TSPAN26
Links

HGNC:1666

NCBI Gene ID: 951

neXtProt AC: NX_P11049

UniProt: P11049
Chr Location

19q13.33; chr19:49335171-49343335 (+) GRCh38

MGI Vertebrate Homology

Cd37 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CD37
Protein SuperFamily

Tetraspanin
Gene Tree

Cd37

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

132
Endonuclease-mediated

5
Gene trapped

123
Targeted

4
Incidental Mutations

CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in reduced levels of IgG1 immunoglobulins and impaired antibody response to T cell dependent antigens.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

1
cDNA Data

48
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cd37

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All Sequences

65
RefSeq

10
UniProt

8
CCDS

CCDS21237.1, CCDS71958.1

Ensembl

ENSMUSG00000030798 (Evidence)
NCBI Gene

12493

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030798	Ensembl Gene Model \| MGI Sequence Detail	5484	C57BL/6J	± kb
transcript	ENSMUST00000033063	Ensembl \| MGI Sequence Detail	1268	Not Applicable
polypeptide	ENSMUSP00000033063	Ensembl \| MGI Sequence Detail	303	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000005170 CD37 molecule

(term hierarchy)
InterPro Domains

IPR000301 Tetraspanin, animals

IPR018503 Tetraspanin, conserved site

IPR008952 Tetraspanin, EC2 domain superfamily

IPR018499 Tetraspanin/Peripherin
GlyGen

Q61470 4 sites, 1 O-linked glycan (1 site)

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All nucleic 51

Genomic 3

cDNA 48

Microarray probesets 4

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MGD-MRK-1850

Summaries

All 47

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 22
Earliest

J:12638 Wright MD, et al., Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication. Int Immunol. 1993 Feb;5(2):209-16
Latest

J:328898 Peeters R, et al., Fatty acid metabolism in aggressive B-cell lymphoma is inhibited by tetraspanin CD37. Nat Commun. 2022 Sep 13;13(1):5371

TSS for Cd37:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr72361	Chr7:44888816-44888834 (-)	-286 bp
Tssr72360	Chr7:44888799-44888811 (-)	-266 bp
Tssr72359	Chr7:44888762-44888774 (-)	-229 bp
Tssr72358	Chr7:44888728-44888744 (-)	-197 bp
Tssr72357	Chr7:44888712-44888719 (-)	-177 bp
Tssr72356	Chr7:44888702-44888711 (-)	-168 bp
Tssr72355	Chr7:44888532-44888557 (-)	-6 bp
Tssr72354	Chr7:44888492-44888527 (-)	29 bp
Tssr72353	Chr7:44888465-44888490 (-)	61 bp
Tssr72352	Chr7:44888218-44888288 (-)	286 bp
Tssr72351	Chr7:44888150-44888180 (-)	374 bp
Tssr72350	Chr7:44884886-44884902 (-)	3,645 bp
Tssr72349	Chr7:44883707-44883739 (-)	4,816 bp
Tssr72348	Chr7:44883148-44883169 (-)	5,380 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24