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Ddx4 Gene Detail
Summary
  • Symbol
    Ddx4
  • Name
    DEAD box helicase 4
  • Synonyms
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 4, Mvh, mvh / m'vasa, VASA
  • Feature Type
    protein coding gene
  • IDs
    MGI:102670
    NCBI Gene: 13206
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:112734867-112789009 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 63.87 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1258 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102670
 protein coding gene Chr13:112734867-112790342 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020938
 protein coding gene Chr13:115161415-115215891 (-)
A/J MGP_AJ_G0020888
 protein coding gene Chr13:110566710-110622157 (-)
AKR/J MGP_AKRJ_G0020863
 protein coding gene Chr13:113908670-113963063 (-)
BALB/cJ MGP_BALBcJ_G0020888
 protein coding gene Chr13:111268798-111322894 (-)
C3H/HeJ MGP_C3HHeJ_G0020677
 protein coding gene Chr13:113705208-113760159 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021324
 protein coding gene Chr13:118595648-118652660 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018893
 protein coding gene Chr13:105865413-105918233 (-)
CAST/EiJ MGP_CASTEiJ_G0020197
 protein coding gene Chr13:113317753-113376338 (-)
CBA/J MGP_CBAJ_G0020639
 protein coding gene Chr13:123173257-123233755 (-)
DBA/2J MGP_DBA2J_G0020762
 protein coding gene Chr13:110282883-110337500 (-)
FVB/NJ MGP_FVBNJ_G0020746
 protein coding gene Chr13:108973279-109029763 (-)
LP/J MGP_LPJ_G0020838
 protein coding gene Chr13:115209346-115268470 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020774
 protein coding gene Chr13:123447966-123504680 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021360
 protein coding gene Chr13:113357491-113412730 (-)
PWK/PhJ MGP_PWKPhJ_G0019950
 protein coding gene Chr13:109018993-109074331 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019772
 protein coding gene Chr13:109686218-109739953 (-)
WSB/EiJ MGP_WSBEiJ_G0020254
 protein coding gene Chr13:113963339-114019292 (-)



Homology
more
  • Human Ortholog
    DDX4, DEAD-box helicase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX4, DEAD-box helicase 4
  • Synonyms
    VASA
  • Links
    NCBI Gene ID: 54514
    neXtProt AC: NX_Q9NQI0
    UniProt: Q9NQI0

  • Chr Location
    5q11.2; chr5:55738017-55817157 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Spermatogenesis is blocked in homozygous mutant mice, resulting in male infertility. Female mutant mice are fertile and do not exhibit any obvious reproductive defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1581
  • Tissues
    94
  • cDNA Data
    22
  • Literature Summary
    339
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021758 Ensembl Gene Model | MGI Sequence Detail 54143 C57BL/6J ±  kb
    transcript ENSMUST00000099166 Ensembl | MGI Sequence Detail 3012 Not Applicable  
    polypeptide ENSMUSP00000096769 Ensembl | MGI Sequence Detail 728 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000031218 probable ATP-dependent RNA helicase DDX4
      (term hierarchy)
    • PDB
      5JIU
    • EC
      3.6.4.13
    • InterPro Domains
      IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
      IPR011545 DEAD/DEAH box helicase domain
      IPR001650 Helicase, C-terminal domain-like
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR014014 RNA helicase, DEAD-box type, Q motif
    • GlyGen
      Q61496 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 23
      Primer pair 21
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-19572, MGI:2145395
    References
    more
    • Summaries
      All 405
      Developmental Gene Expression 339
      Gene Ontology 26
      Phenotypes 31
    • Earliest
      J:21929 Fujiwara Y, et al., Isolation of a DEAD-family protein gene that encodes a murine homolog of Drosophila vasa and its specific expression in germ cell lineage. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12258-62
    • Latest
      J:354208 Dong MZ, et al., Protein phosphatase 4 maintains the survival of primordial follicles by regulating autophagy in oocytes. Cell Death Dis. 2024 Sep 8;15(9):658
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    10/22/2024
    MGI 6.24     		The Jackson Laboratory