Foxs1 MGI Mouse Gene Detail - MGI:95546

Symbol

Foxs1
Name

forkhead box S1
Synonyms

Fkh3, Fkhl18, FREAC10

Feature Type

protein coding gene
IDs

MGI:95546
NCBI Gene: 14239
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:152773818-152775128 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 75.41 cM, cytoband H2
Mapping Data

2 experiments

SNPs within 2kb

143 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95546	protein coding gene	Chr2:152773818-152775128 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026681	protein coding gene	Chr2:157534867-157536177 (-)
A/J	MGP_AJ_G0026647	protein coding gene	Chr2:151230345-151231654 (-)
AKR/J	MGP_AKRJ_G0026617	protein coding gene	Chr2:155652949-155654259 (-)
BALB/cJ	MGP_BALBcJ_G0026656	protein coding gene	Chr2:151541306-151542616 (-)
C3H/HeJ	MGP_C3HHeJ_G0026399	protein coding gene	Chr2:156022410-156023720 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027105	protein coding gene	Chr2:162108809-162110119 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024476	protein coding gene	Chr2:144822464-144823773 (-)
CAST/EiJ	MGP_CASTEiJ_G0025860	protein coding gene	Chr2:156281135-156282445 (-)
CBA/J	MGP_CBAJ_G0026377	protein coding gene	Chr2:168068889-168070199 (-)
DBA/2J	MGP_DBA2J_G0026513	protein coding gene	Chr2:150440955-150442265 (-)
FVB/NJ	MGP_FVBNJ_G0026479	protein coding gene	Chr2:148908224-148909534 (-)
LP/J	MGP_LPJ_G0026617	protein coding gene	Chr2:157680568-157681878 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026500	protein coding gene	Chr2:172133792-172135101 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027161	protein coding gene	Chr2:155546895-155548205 (-)
PWK/PhJ	MGP_PWKPhJ_G0025594	protein coding gene	Chr2:149970019-149971329 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025397	protein coding gene	Chr2:154379893-154381203 (-)
WSB/EiJ	MGP_WSBEiJ_G0025930	protein coding gene	Chr2:156450984-156452294 (-)

Human Ortholog

FOXS1, forkhead box S1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FOXS1, forkhead box S1
Synonyms

FKHL18, FREAC10
Links

HGNC:3735

NCBI Gene ID: 2307

neXtProt AC: NX_O43638

UniProt: O43638
Chr Location

20q11.21; chr20:31844303-31845604 (-) GRCh38

MGI Vertebrate Homology

Foxs1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FOXS1
Gene Tree

Foxs1

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
1 images
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Foxs1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for one reporter allele display enhanced rotarod performance and increased male resistance to diet-induced obesity. Homozygotes for another reporter allele show impaired testicular vasculature, including blood accumulation in fetal testis and marked apoptosis of periendothelial cells.

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All GO Annotations

15
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

795
Tissues

74
cDNA Data

21
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FOXS1

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All Sequences

33
RefSeq

2
UniProt

2
CCDS

CCDS16901.1

Ensembl

ENSMUSG00000074676 (Evidence)
NCBI Gene

14239

			Length	Strain/Species	Flank
genomic	14239	NCBI Gene Model \| MGI Sequence Detail	1311	C57BL/6J	± kb
transcript	NM_010226	RefSeq \| MGI Sequence Detail	1311	C57BL/6
polypeptide	Q61574	UniProt \| EBI \| MGI Sequence Detail	329	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007649 forkhead box protein S1

(term hierarchy)
InterPro Domains

IPR050211 Forkhead box domain-containing protein

IPR047364 Forkhead box protein S1, Forkhead domain

IPR001766 Fork head domain

IPR018122 Fork head domain conserved site1

IPR030456 Fork head domain conserved site 2

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 25

Genomic 1

cDNA 22

Primer pair 1

Other 1

Microarray probesets 2

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MGD-MRK-9815

Summaries

All 40

Developmental Gene Expression 10

Gene Ontology 3

Phenotypes 11
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:298159 Wang S, et al., FOXS1 is regulated by GLI1 and miR-125a-5p and promotes cell proliferation and EMT in gastric cancer. Sci Rep. 2019 Mar 27;9(1):5281

TSS for Foxs1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26875	Chr2:152775122-152775138 (-)	-2 bp
Tssr26874	Chr2:152775085-152775109 (-)	31 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24