Zfp354a MGI Mouse Gene Detail - MGI:103172

Symbol

Zfp354a
Name

zinc finger protein 354A
Synonyms

kid1, Tcf17

Feature Type

protein coding gene
IDs

MGI:103172
NCBI Gene: 21408
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:50950084-50963626 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 30.97 cM
Mapping Data

4 experiments

SNPs within 2kb

620 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103172	protein coding gene	Chr11:50950052-50963626 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018264	protein coding gene	Chr11:50262916-50276132 (+)
A/J	MGP_AJ_G0018233	protein coding gene	Chr11:48371921-48383749 (+)
AKR/J	MGP_AKRJ_G0018203	protein coding gene	Chr11:49888515-49902148 (+)
BALB/cJ	MGP_BALBcJ_G0018203	protein coding gene	Chr11:48662462-48675834 (+)
C3H/HeJ	MGP_C3HHeJ_G0018014	protein coding gene	Chr11:49865968-49876734 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018653	protein coding gene	Chr11:51793784-51808314 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016306	protein coding gene	Chr11:45964600-45978196 (+)
CAST/EiJ	MGP_CASTEiJ_G0017577	protein coding gene	Chr11:49899563-49928050 (+)
CBA/J	MGP_CBAJ_G0017990	protein coding gene	Chr11:54201742-54223056 (+)
DBA/2J	MGP_DBA2J_G0018097	protein coding gene	Chr11:48103527-48104339 (+)
FVB/NJ	MGP_FVBNJ_G0018092	protein coding gene	Chr11:47789937-47803110 (+)
LP/J	MGP_LPJ_G0018173	protein coding gene	Chr11:50659819-50672547 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018115	protein coding gene	Chr11:55642897-55658894 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018696	protein coding gene	Chr11:49995453-50009186 (+)
PWK/PhJ	MGP_PWKPhJ_G0017355	protein coding gene	Chr11:48541807-48556177 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017150	protein coding gene	Chr11:49692697-49708988 (+)
WSB/EiJ	MGP_WSBEiJ_G0017627	protein coding gene	Chr11:49650578-49664852 (+)

Human Ortholog

ZNF354A, zinc finger protein 354A

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF354A, zinc finger protein 354A
Synonyms

EZNF, HEL104, HKL1, KID-1, KID1, TCF17
Links

HGNC:11628

NCBI Gene ID: 6940

neXtProt AC: NX_O60765

UniProt: O60765
Chr Location

5q35.3; chr5:178711512-178730659 (-) GRCh38

MGI Vertebrate Homology

Zfp354a stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ZNF354A
Gene Tree

Zfp354a

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Chemically induced (other)

1
Endonuclease-mediated

1
Genomic Mutations

1 involving Zfp354a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

898
Tissues

170
cDNA Data

23
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

64
RefSeq

20
UniProt

3
CCDS

CCDS24648.1, CCDS83802.1, CCDS83803.1

Ensembl

ENSMUSG00000020364 (Evidence)
NCBI Gene

21408

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020364	Ensembl Gene Model \| MGI Sequence Detail	13543	C57BL/6J	± kb
transcript	ENSMUST00000109119	Ensembl \| MGI Sequence Detail	2078	Not Applicable
polypeptide	ENSMUSP00000104747	Ensembl \| MGI Sequence Detail	573	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017848 zinc finger protein 354A

(term hierarchy)
InterPro Domains

IPR036051 KRAB domain superfamily

IPR001909 Krueppel-associated box

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 26

cDNA 23

Primer pair 2

Other 1

Microarray probesets 3

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MGD-MRK-24038, MGI:2144535

Summaries

All 44

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 6
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zfp354a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101270	Chr11:50950058-50950134 (+)	12 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24