Prg2 MGI Mouse Gene Detail - MGI:103294 - proteoglycan 2, bone marrow

Symbol

Prg2
Name

proteoglycan 2, bone marrow
Synonyms

EMBP, mMBP, mMBP-1

Feature Type

protein coding gene
IDs

MGI:103294
NCBI Gene: 19074
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr2:84810805-84813976 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 49.45 cM
Mapping Data

4 experiments

SNPs within 2kb

140 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103294	protein coding gene	Chr2:84810805-84813977 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025917	protein coding gene	Chr2:85686621-85689790 (+)
A/J	MGP_AJ_G0025891	protein coding gene	Chr2:82365239-82368420 (+)
AKR/J	MGP_AKRJ_G0025861	protein coding gene	Chr2:84496080-84499263 (+)
BALB/cJ	MGP_BALBcJ_G0025888	protein coding gene	Chr2:82495783-82498964 (+)
C3H/HeJ	MGP_C3HHeJ_G0025647	protein coding gene	Chr2:84727209-84730392 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026334	protein coding gene	Chr2:88341024-88344195 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023736	protein coding gene	Chr2:79192406-79195597 (+)
CAST/EiJ	MGP_CASTEiJ_G0025108	protein coding gene	Chr2:85274125-85277274 (+)
CBA/J	MGP_CBAJ_G0025628	protein coding gene	Chr2:91492301-91495480 (+)
DBA/2J	MGP_DBA2J_G0025759	protein coding gene	Chr2:81902299-81905478 (+)
FVB/NJ	MGP_FVBNJ_G0025722	protein coding gene	Chr2:81157115-81160274 (+)
LP/J	MGP_LPJ_G0025847	protein coding gene	Chr2:85476786-85479967 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025752	protein coding gene	Chr2:93813127-93816296 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026390	protein coding gene	Chr2:84744044-84747223 (+)
PWK/PhJ	MGP_PWKPhJ_G0024852	protein coding gene	Chr2:81744881-81749274 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024656	protein coding gene	Chr2:84864151-84867325 (+)
WSB/EiJ	MGP_WSBEiJ_G0025178	protein coding gene	Chr2:85399355-85403981 (+)

Human Ortholog

PRG2, proteoglycan 2, pro eosinophil major basic protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRG2, proteoglycan 2, pro eosinophil major basic protein
Synonyms

BMPG, MBP, MBP1, proMBP
Links

HGNC:9362

NCBI Gene ID: 5553

neXtProt AC: NX_P13727

UniProt: P13727
Chr Location

11q12.1; chr11:57386780-57390650 (-) GRCh38

MGI Vertebrate Homology

Prg2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PRG2
Gene Tree

Prg2

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

7
Genomic Mutations

3 involving Prg2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display an essentially normal phenotype although fine structure changes occur in eosinophils.

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

748
Tissues

17
cDNA Data

6
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

32
RefSeq

4
UniProt

2
CCDS

CCDS16198.1

Ensembl

ENSMUSG00000027073 (Evidence)
NCBI Gene

19074

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027073	Ensembl Gene Model \| MGI Sequence Detail	3172	C57BL/6J	± kb
transcript	ENSMUST00000028467	Ensembl \| MGI Sequence Detail	838	Not Applicable
polypeptide	ENSMUSP00000028467	Ensembl \| MGI Sequence Detail	223	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013206 bone marrow proteoglycan

(term hierarchy)
InterPro Domains

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily

IPR002352 Eosinophil major basic protein

IPR033816 Eosinophil major basic protein, C-type lectin-like domain
GlyGen

Q61878 3 sites

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All nucleic 16

Genomic 9

cDNA 6

Primer pair 1

Microarray probesets 3

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MGD-MRK-24176

Summaries

All 58

Developmental Gene Expression 6

Gene Ontology 5

Phenotypes 27
Earliest

J:28584 Larson KA, et al., The identification and cloning of a murine major basic protein gene expressed in eosinophils. J Immunol. 1995 Sep 15;155(6):3002-12
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Prg2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18716	Chr2:84810802-84810806 (+)	-1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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