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Dmc1 Gene Detail
Summary
  • Symbol
    Dmc1
  • Name
    DNA meiotic recombinase 1
  • Synonyms
    Dmc1, Dmc1h, Mei11, sgdp
  • Feature Type
    protein coding gene
  • IDs
    MGI:105393
    NCBI Gene: 13404
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79445698-79489310 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.79 cM, cytoband E
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    930 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105393
 protein coding gene Chr15:79445698-79489362 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022078
 protein coding gene Chr15:79840178-79893324 (-)
A/J MGP_AJ_G0022039
 protein coding gene Chr15:77085931-77129764 (-)
AKR/J MGP_AKRJ_G0022014
 protein coding gene Chr15:79240120-79288607 (-)
BALB/cJ MGP_BALBcJ_G0022045
 protein coding gene Chr15:77092806-77149734 (-)
C3H/HeJ MGP_C3HHeJ_G0021816
 protein coding gene Chr15:79233069-79280122 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022488
 protein coding gene Chr15:82986830-83037423 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020018
 protein coding gene Chr15:73565073-73609677 (-)
CAST/EiJ MGP_CASTEiJ_G0021337
 protein coding gene Chr15:79939750-79986214 (-)
CBA/J MGP_CBAJ_G0021781
 protein coding gene Chr15:85569067-85623440 (-)
DBA/2J MGP_DBA2J_G0021910
 protein coding gene Chr15:76572944-76621218 (-)
FVB/NJ MGP_FVBNJ_G0021888
 protein coding gene Chr15:75599302-75645158 (-)
LP/J MGP_LPJ_G0021978
 protein coding gene Chr15:80034577-80079489 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021908
 protein coding gene Chr15:90670268-90723212 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022502
 protein coding gene Chr15:79254416-79305162 (-)
PWK/PhJ MGP_PWKPhJ_G0021079
 protein coding gene Chr15:76585143-76630428 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020916
 protein coding gene Chr15:79069995-79113379 (-)
WSB/EiJ MGP_WSBEiJ_G0021389
 protein coding gene Chr15:79637612-79690303 (-)



Homology
more
  • Human Ortholog
    DMC1, DNA meiotic recombinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DMC1, DNA meiotic recombinase 1
  • Synonyms
    dJ199H16.1, DMC1H, LIM15
  • Links
    NCBI Gene ID: 11144
    neXtProt AC: NX_Q14565
    UniProt: Q14565

  • Chr Location
    22q13.1; chr22:38509147-38570204 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dmc1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 4 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    2 images
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations are sterile with failure of homologous pairing in meiotic prophase in males and disrupted oogenesis in embryonic females with absence of germ cells in the adult ovary.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    30
  • cDNA Data
    19
  • Literature Summary
    71
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022429 Ensembl Gene Model | MGI Sequence Detail 43613 C57BL/6J ±  kb
    transcript ENSMUST00000023065 Ensembl | MGI Sequence Detail 2219 Not Applicable  
    polypeptide ENSMUSP00000023065 Ensembl | MGI Sequence Detail 340 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000006536 meiotic recombination protein DMC1/LIM15
      (term hierarchy)
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR013632 DNA recombination and repair protein Rad51-like, C-terminal
      IPR016467 DNA recombination and repair protein, RecA-like
      IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
      IPR020587 DNA recombination and repair protein RecA, monomer-monomer interface
      IPR010995 DNA repair Rad51/transcription factor NusA, alpha-helical
      IPR011940 Meiotic recombination protein Dmc1
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 9
      cDNA 19
      Primer pair 6
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33063, MGI:1890405
    References
    more
    • Summaries
      All 187
      Developmental Gene Expression 71
      Diseases 2
      Gene Ontology 26
      Phenotypes 68
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:347775 Yoshimura S, et al., Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions. Nat Commun. 2024 Apr 29;15(1):3330
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory