Rhoc MGI Mouse Gene Detail - MGI:106028 - ras homolog family member C

Symbol

Rhoc
Name

ras homolog family member C
Synonyms

Arh9, Arhc

Feature Type

protein coding gene
IDs

MGI:106028
NCBI Gene: 11853
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr3:104696350-104701775 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 45.86 cM
Mapping Data

2 experiments

SNPs within 2kb

174 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106028	protein coding gene	Chr3:104695691-104701775 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027710	protein coding gene	Chr3:106112311-106117806 (+)
A/J	MGP_AJ_G0027670	protein coding gene	Chr3:102730924-102736398 (+)
AKR/J	MGP_AKRJ_G0027635	protein coding gene	Chr3:105257080-105262565 (+)
BALB/cJ	MGP_BALBcJ_G0027682	protein coding gene	Chr3:102515910-102521396 (+)
C3H/HeJ	MGP_C3HHeJ_G0027412	protein coding gene	Chr3:105638615-105644058 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028126	protein coding gene	Chr3:110076271-110081768 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025466	protein coding gene	Chr3:98840768-98847128 (+)
CAST/EiJ	MGP_CASTEiJ_G0026868	protein coding gene	Chr3:104753570-104759250 (+)
CBA/J	MGP_CBAJ_G0027387	protein coding gene	Chr3:113823290-113828738 (+)
DBA/2J	MGP_DBA2J_G0027529	protein coding gene	Chr3:101984756-101990241 (+)
FVB/NJ	MGP_FVBNJ_G0027497	protein coding gene	Chr3:99906087-99912796 (+)
LP/J	MGP_LPJ_G0027636	protein coding gene	Chr3:107493370-107498784 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027527	protein coding gene	Chr3:119946924-119952394 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028181	protein coding gene	Chr3:104817408-104822861 (+)
PWK/PhJ	MGP_PWKPhJ_G0026594	protein coding gene	Chr3:101760692-101766330 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026415	protein coding gene	Chr3:102854147-102859539 (+)
WSB/EiJ	MGP_WSBEiJ_G0026948	protein coding gene	Chr3:105395478-105401147 (+)

Human Ortholog

RHOC, ras homolog family member C

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RHOC, ras homolog family member C
Synonyms

ARH9, ARHC, H9, RHOH9
Links

HGNC:669

NCBI Gene ID: 389

neXtProt AC: NX_P08134

UniProt: P08134
Chr Location

1p13.2; chr1:112701127-112707434 (-) GRCh38

MGI Vertebrate Homology

Rhoc stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RHOC
Gene Tree

Rhoc

less

References

1 with disease annotations

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Gene trapped

16
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Rhoc
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available

Homozygous null mutation in this gene results in no abnormal phenotype, except for reduced stress fiber formation in serum starved fibroblasts. However, in combination with Tg(MMTV-PyVT)634Mul mice, metastatic potential of tumors and tumor cell motility are decreased.

less

All GO Annotations

39
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

2
cDNA Data

137
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RHOC

Xenbase rhoc

ZFIN rhoca, rhocb

less

All Sequences

50
RefSeq

4
UniProt

3
CCDS

CCDS17704.1

Ensembl

ENSMUSG00000002233 (Evidence)
NCBI Gene

11853

			Length	Strain/Species	Flank
genomic	11853	NCBI Gene Model \| MGI Sequence Detail	5426	C57BL/6J	± kb
transcript	NM_001291859	RefSeq \| MGI Sequence Detail	1092	C57BL/6
polypeptide	Q62159	UniProt \| EBI \| MGI Sequence Detail	193	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000013978 Rho-related GTP-binding protein RhoC

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase

IPR003578 Small GTPase Rho

IPR005225 Small GTP-binding protein domain
GlyGen

Q62159 1 site, 1 O-linked glycan (1 site)

less

All nucleic 137

cDNA 137

Microarray probesets 4

less

MGD-MRK-33711, MGI:2139675

Summaries

All 59

Developmental Gene Expression 4

Diseases 1

Gene Ontology 12

Phenotypes 14
Earliest

J:4309 Miki T, et al., Oncogene ect2 is related to regulators of small GTP-binding proteins [published erratum appears in Nature 1993 Aug 19;364(6439):737]. Nature. 1993 Apr 1;362(6419):462-5
Latest

J:327336 Bertol JW, et al., TWIST1 interacts with beta/delta-catenins during neural tube development and regulates fate transition in cranial neural crest cells. Development. 2022 Aug 1;149(15):dev200068

TSS for Rhoc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31056	Chr3:104695888-104695911 (+)	-450 bp
Tssr31057	Chr3:104696109-104696157 (+)	-217 bp
Tssr31058	Chr3:104696158-104696171 (+)	-185 bp
Tssr31059	Chr3:104696342-104696362 (+)	2 bp
Tssr31060	Chr3:104701337-104701357 (+)	4,997 bp
Tssr31061	Chr3:104701398-104701426 (+)	5,062 bp
Tssr31062	Chr3:104701597-104701621 (+)	5,259 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24