Cd180 MGI Mouse Gene Detail - MGI:1194924

Symbol

Cd180
Name

CD180 antigen
Synonyms

Ly78, RP105

Feature Type

protein coding gene
IDs

MGI:1194924
NCBI Gene: 17079
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr13:102830055-102843139 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 54.92 cM
Mapping Data

4 experiments

SNPs within 2kb

438 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1194924	protein coding gene	Chr13:102830055-102876137 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020898	protein coding gene	Chr13:104744500-104796830 (+)
A/J	MGP_AJ_G0020849	protein coding gene	Chr13:100661554-100707650 (+)
AKR/J	MGP_AKRJ_G0020824	protein coding gene	Chr13:103723783-103771728 (+)
BALB/cJ	MGP_BALBcJ_G0020849	protein coding gene	Chr13:101371245-101418250 (+)
C3H/HeJ	MGP_C3HHeJ_G0020638	protein coding gene	Chr13:103451875-103509060 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021283	protein coding gene	Chr13:107884682-107935754 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018853	protein coding gene	Chr13:96323974-96369800 (+)
CAST/EiJ	MGP_CASTEiJ_G0020157	protein coding gene	Chr13:102916123-102966448 (+)
CBA/J	MGP_CBAJ_G0020600	protein coding gene	Chr13:112116920-112172690 (+)
DBA/2J	MGP_DBA2J_G0020724	protein coding gene	Chr13:100425095-100472440 (+)
FVB/NJ	MGP_FVBNJ_G0020706	protein coding gene	Chr13:99119354-99165785 (+)
LP/J	MGP_LPJ_G0020798	protein coding gene	Chr13:104765698-104814244 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020734	protein coding gene	Chr13:112312535-112361908 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021322	protein coding gene	Chr13:103197653-103244029 (+)
PWK/PhJ	MGP_PWKPhJ_G0019910	protein coding gene	Chr13:99164298-99211808 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019732	protein coding gene	Chr13:99414137-99462998 (+)
WSB/EiJ	MGP_WSBEiJ_G0020215	protein coding gene	Chr13:103660067-103674562 (+)

Human Ortholog

CD180, CD180 molecule

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD180, CD180 molecule
Synonyms

LY64, Ly78, RP105
Links

HGNC:6726

NCBI Gene ID: 4064

neXtProt AC: NX_Q99467

UniProt: Q99467
Chr Location

5q12.3; chr5:67179613-67196799 (-) GRCh38

MGI Vertebrate Homology

Cd180 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CD180
Gene Tree

Cd180

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Phenotype Summary

4 phenotypes from 1 allele in 2 genetic backgrounds
14 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

3
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available

Mice homozygous for a null mutation showed impaired proliferative and humoral immune responses of B cells to lipopolysaccharides.

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All GO Annotations

23
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

9

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN cd180

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All Sequences

46
RefSeq

4
UniProt

6
CCDS

CCDS26741.1

Ensembl

ENSMUSG00000021624 (Evidence)
NCBI Gene

17079

			Length	Strain/Species	Flank
genomic	17079	NCBI Gene Model \| MGI Sequence Detail	13085	C57BL/6J	± kb
transcript	NM_008533	RefSeq \| MGI Sequence Detail	2326	NOD
polypeptide	Q62192	UniProt \| EBI \| MGI Sequence Detail	661	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000001298 CD180 molecule

(term hierarchy)
PDB

3T6Q
InterPro Domains

IPR041281 CD180, leucine-rich repeat

IPR000483 Cysteine-rich flanking region, C-terminal

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR050328 Multifunctional Developmental and Immune Receptor
GlyGen

Q62192 10 sites, 5 N-linked glycans (5 sites)

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All nucleic 10

cDNA 10

Microarray probesets 3

Summaries

All 54

Gene Ontology 8

Phenotypes 21
Earliest

J:25726 Miyake K, et al., RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family. J Immunol. 1995 Apr 1;154(7):3333-40
Latest

J:336162 Kani K, et al., The innate immune receptor RP105 promotes metabolic syndrome by altering gut microbiota composition and intestinal barrier function. Biochem Biophys Res Commun. 2023 Jul 5;664:77-85

TSS for Cd180:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120876	Chr13:102828473-102828479 (+)	-1,579 bp
Tssr120877	Chr13:102830030-102830094 (+)	7 bp
Tssr120878	Chr13:102830104-102830115 (+)	55 bp
Tssr120879	Chr13:102830157-102830168 (+)	108 bp
Tssr120880	Chr13:102835007-102835023 (+)	4,960 bp
Tssr120881	Chr13:102837782-102837804 (+)	7,738 bp
Tssr120882	Chr13:102842588-102842597 (+)	12,538 bp
Tssr120883	Chr13:102842797-102842801 (+)	12,744 bp
Tssr120884	Chr13:102843050-102843061 (+)	13,001 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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