Nr0b2 MGI Mouse Gene Detail - MGI:1346344 - nuclear receptor subfamily 0, group B, member 2

Symbol

Nr0b2
Name

nuclear receptor subfamily 0, group B, member 2
Synonyms

SHP, SHP-1, small heterodimer partner

Feature Type

protein coding gene
IDs

MGI:1346344
NCBI Gene: 23957
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr4:133280687-133283847 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 66.25 cM
Mapping Data

5 experiments

SNPs within 2kb

187 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346344	protein coding gene	Chr4:133280687-133283997 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028898	protein coding gene	Chr4:135818900-135822043 (+)
A/J	MGP_AJ_G0028857	protein coding gene	Chr4:130130394-130133525 (+)
AKR/J	MGP_AKRJ_G0028810	protein coding gene	Chr4:133828999-133832135 (+)
BALB/cJ	MGP_BALBcJ_G0028880	protein coding gene	Chr4:130762200-130765368 (+)
C3H/HeJ	MGP_C3HHeJ_G0028594	protein coding gene	Chr4:134080209-134083340 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029322	protein coding gene	Chr4:140691628-140694796 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026593	protein coding gene	Chr4:123200866-123203825 (+)
CAST/EiJ	MGP_CASTEiJ_G0028027	protein coding gene	Chr4:132197679-132200755 (+)
CBA/J	MGP_CBAJ_G0028560	protein coding gene	Chr4:144376917-144380048 (+)
DBA/2J	MGP_DBA2J_G0028709	protein coding gene	Chr4:130549799-130553013 (+)
FVB/NJ	MGP_FVBNJ_G0028676	protein coding gene	Chr4:129430020-129433481 (+)
LP/J	MGP_LPJ_G0028810	protein coding gene	Chr4:135932922-135936065 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028702	protein coding gene	Chr4:148884032-148887278 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029360	protein coding gene	Chr4:134252984-134256152 (+)
PWK/PhJ	MGP_PWKPhJ_G0027748	protein coding gene	Chr4:127267959-127271162 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027574	protein coding gene	Chr4:130083214-130086672 (+)
WSB/EiJ	MGP_WSBEiJ_G0028107	protein coding gene	Chr4:134431403-134434522 (+)

Human Ortholog

NR0B2, nuclear receptor subfamily 0 group B member 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NR0B2, nuclear receptor subfamily 0 group B member 2
Synonyms

SHP, SHP1
Links

HGNC:7961

NCBI Gene ID: 8431

neXtProt AC: NX_Q15466

UniProt: Q15466
Chr Location

1p36.11; chr1:26911489-26913975 (-) GRCh38

MGI Vertebrate Homology

Nr0b2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NR0B2
Gene Tree

Nr0b2

Diseases

2 with human NR0B2 associations

				Human Disease	Mouse Models
				obesity IDs obesity DOID:9970 EFO:0001073 ICD10CM:E66.9 ICD9CM:278.00 MESH:D009765 NCI:C159658 OMIM:601665 UMLS_CUI:C0028754
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 6 alleles in 5 genetic backgrounds
3 phenotypes from multigenic genotypes
74 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

4
Radiation induced

1
Targeted

9
Genomic Mutations

4 involving Nr0b2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted null mutation are viable and fertile and exhibit no major defects in cholesterol metabolism under normal conditions. Under high cholesterol and cholic acid or iodine-deficient diets, mice exhibit decreased lipid levels.

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All GO Annotations

58
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

882
Tissues

157
cDNA Data

20
Literature Summary

18

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nr0b2

ZFIN nr0b2a, nr0b2b

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All Sequences

32
RefSeq

2
UniProt

1
CCDS

CCDS18751.1

Ensembl

ENSMUSG00000037583 (Evidence)
NCBI Gene

23957

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037583	Ensembl Gene Model \| MGI Sequence Detail	3161	C57BL/6J	± kb
transcript	ENSMUST00000042706	Ensembl \| MGI Sequence Detail	1132	Not Applicable
polypeptide	ENSMUSP00000039175	Ensembl \| MGI Sequence Detail	260	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011391 nuclear receptor subfamily 0 group B member 2

(term hierarchy)
PDB

1YMT, 4NUF
InterPro Domains

IPR001723 Nuclear hormone receptor

IPR000536 Nuclear hormone receptor, ligand-binding domain

IPR035500 Nuclear hormone receptor-like domain superfamily

IPR033544 Nuclear receptor subfamily 0 group B member 1/2

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All nucleic 24

cDNA 20

Primer pair 3

Other 1

Microarray probesets 3

Summaries

All 165

Developmental Gene Expression 18

Gene Ontology 11

Phenotypes 74
Earliest

J:33440 Seol W, et al., An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science. 1996 May 31;272(5266):1336-9
Latest

J:350501 Vidana Gamage HE, et al., NR0B2 re-educates myeloid immune cells to reduce regulatory T cell expansion and progression of breast and other solid tumors. Cancer Lett. 2024 Jun 20;597:217042

TSS for Nr0b2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39489	Chr4:133280681-133280704 (+)	6 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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