Tead4 MGI Mouse Gene Detail - MGI:106907 - TEA domain family member 4

Symbol

Tead4
Name

TEA domain family member 4
Synonyms

Etfr2, ETFR-2a, Rtef1, Tcf13r1, TEAD-4, Tef3, TEF-3, Tefr, Tefr1a

Feature Type

protein coding gene
IDs

MGI:106907
NCBI Gene: 21679
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr6:128204106-128277776 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 62.92 cM
Mapping Data

2 experiments

SNPs within 2kb

2214 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106907	protein coding gene	Chr6:128201251-128277786 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031319	protein coding gene	Chr6:131823457-131900009 (-)
A/J	MGP_AJ_G0031290	protein coding gene	Chr6:126770740-126844908 (-)
AKR/J	MGP_AKRJ_G0031218	protein coding gene	Chr6:130184951-130258591 (-)
BALB/cJ	MGP_BALBcJ_G0031297	protein coding gene	Chr6:126339664-126412410 (-)
C3H/HeJ	MGP_C3HHeJ_G0031021	protein coding gene	Chr6:130321731-130397515 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031756	protein coding gene	Chr6:135251286-135331970 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028902	protein coding gene	Chr6:123972862-124046091 (-)
CAST/EiJ	MGP_CASTEiJ_G0030403	protein coding gene	Chr6:130604223-130681185 (-)
CBA/J	MGP_CBAJ_G0030982	protein coding gene	Chr6:140467284-140542757 (-)
DBA/2J	MGP_DBA2J_G0031138	protein coding gene	Chr6:125663615-125736240 (-)
FVB/NJ	MGP_FVBNJ_G0031088	protein coding gene	Chr6:124586342-124659771 (-)
LP/J	MGP_LPJ_G0031218	protein coding gene	Chr6:131945055-132019136 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031126	protein coding gene	Chr6:144315644-144393566 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031789	protein coding gene	Chr6:130189450-130267960 (-)
PWK/PhJ	MGP_PWKPhJ_G0030118	protein coding gene	Chr6:123959404-124038384 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029946	protein coding gene	Chr6:128295642-128378929 (-)
WSB/EiJ	MGP_WSBEiJ_G0030487	protein coding gene	Chr6:130570774-130658942 (-)

Human Ortholog

TEAD4, TEA domain transcription factor 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TEAD4, TEA domain transcription factor 4
Synonyms

EFTR-2, hRTEF-1B, RTEF1, TCF13L1, TEF-3, TEF3, TEFR-1
Links

HGNC:11717

NCBI Gene ID: 7004

neXtProt AC: NX_Q15561

UniProt: Q15561
Chr Location

12p13.33; chr12:2959330-3040676 (+) GRCh38

MGI Vertebrate Homology

Tead4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TEAD4
Protein SuperFamily

TEF
Gene Tree

Tead4

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Phenotype Summary

8 phenotypes from 3 alleles in 4 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

86
Endonuclease-mediated

2
Gene trapped

79
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

75 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele die prior to somitogenesis, lack trophoblast stem cells and develop abnormally.

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All GO Annotations

35
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1052
Tissues

224
cDNA Data

45
Literature Summary

36

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tead4

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All Sequences

52
RefSeq

4
UniProt

5
CCDS

CCDS39645.1, CCDS39646.1

Ensembl

ENSMUSG00000030353 (Evidence)
NCBI Gene

21679

			Length	Strain/Species	Flank
genomic	21679	NCBI Gene Model \| MGI Sequence Detail	73671	C57BL/6J	± kb
transcript	NM_011567	RefSeq \| MGI Sequence Detail	3076	Not Specified
polypeptide	Q62296	UniProt \| EBI \| MGI Sequence Detail	427	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016221 transcriptional enhancer factor TEF-3

(term hierarchy)
PDB

3JUA, 4LN0, 5GN0, 5XJD, 5Z2Q, 6L9F, 6SBA
InterPro Domains

IPR000818 TEA/ATTS domain

IPR038096 TEA/ATTS domain superfamily

IPR050937 TEC1/TEAD Transcription Factor

IPR016361 Transcriptional enhancer factor, metazoa

IPR027255 Transcriptional enhancer factor TEF-3 (TEAD4)

IPR041086 YAP binding domain

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All nucleic 61

cDNA 46

Primer pair 12

Other 3

Microarray probesets 7

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MGD-MRK-35368

Summaries

All 95

Developmental Gene Expression 36

Gene Ontology 13

Phenotypes 19
Earliest

J:48110 Burglin TR, The TEA domain: a novel, highly conserved DNA-binding motif [letter]. Cell. 1991 Jul 12;66(1):11-2
Latest

J:352881 Zhu M, et al., Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification. Nat Struct Mol Biol. 2024 Jun;31(6):964-976

TSS for Tead4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr63426	Chr6:128277515-128277525 (-)	256 bp
Tssr63425	Chr6:128277466-128277488 (-)	299 bp
Tssr63424	Chr6:128277416-128277464 (-)	336 bp
Tssr63423	Chr6:128277402-128277407 (-)	371 bp
Tssr63422	Chr6:128277393-128277398 (-)	380 bp
Tssr63421	Chr6:128277325-128277387 (-)	420 bp
Tssr63420	Chr6:128274052-128274070 (-)	3,715 bp
Tssr63419	Chr6:128256093-128256100 (-)	21,679 bp
Tssr63418	Chr6:128221392-128221396 (-)	56,382 bp
Tssr63417	Chr6:128220441-128220466 (-)	57,322 bp
Tssr63416	Chr6:128210807-128210814 (-)	66,965 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24