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Jarid2 Gene Detail
Summary
  • Symbol
    Jarid2
  • Name
    jumonji and AT-rich interaction domain containing 2
  • Synonyms
    Jmj, jumonji
  • Feature Type
    protein coding gene
  • IDs
    MGI:104813
    NCBI Gene: 16468
  • Alliance
    gene page
  • Transcription Start Sites
    35 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:44882950-45075119 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 21.66 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3502 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104813
 protein coding gene Chr13:44881817-45075119 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020504
 protein coding gene Chr13:43403726-43608739 (+)
A/J MGP_AJ_G0020458
 protein coding gene Chr13:41902944-42098482 (+)
AKR/J MGP_AKRJ_G0020436
 protein coding gene Chr13:43065999-43277768 (+)
BALB/cJ MGP_BALBcJ_G0020454
 protein coding gene Chr13:42115407-42309382 (+)
C3H/HeJ MGP_C3HHeJ_G0020253
 protein coding gene Chr13:42916692-43119867 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020887
 protein coding gene Chr13:44728112-44940238 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018474
 protein coding gene Chr13:39989849-40177451 (+)
CAST/EiJ MGP_CASTEiJ_G0019768
 protein coding gene Chr13:42795886-42993703 (+)
CBA/J MGP_CBAJ_G0020214
 protein coding gene Chr13:46608746-46833858 (+)
DBA/2J MGP_DBA2J_G0020336
 protein coding gene Chr13:41465691-41663730 (+)
FVB/NJ MGP_FVBNJ_G0020315
 protein coding gene Chr13:40990029-41184347 (+)
LP/J MGP_LPJ_G0020411
 protein coding gene Chr13:43635358-43837831 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020344
 protein coding gene Chr13:46477993-46691268 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020930
 protein coding gene Chr13:42736024-42932209 (+)
PWK/PhJ MGP_PWKPhJ_G0019523
 protein coding gene Chr13:41588448-41784622 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019353
 protein coding gene Chr13:41399954-41587372 (+)
WSB/EiJ MGP_WSBEiJ_G0019830
 protein coding gene Chr13:43044143-43244429 (+)



Homology
more
  • Human Ortholog
    JARID2, jumonji and AT-rich interaction domain containing 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    JARID2, jumonji and AT-rich interaction domain containing 2
  • Synonyms
    DIDDF, JMJ
  • Links
    NCBI Gene ID: 3720
    neXtProt AC: NX_Q92833
    UniProt: Q92833

  • Chr Location
    6p22.3; chr6:15246069-15522042 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human JARID2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 5 alleles in 8 genetic backgrounds
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants show strain-specific phenotypes, including embryonic death and defective neural tube closure, impaired hematopoiesis and hypoplasia of liver, thymus and spleen. Homozygotes for another mutation die at birth with cardiac defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    996
  • Tissues
    191
  • cDNA Data
    25
  • Literature Summary
    39
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038518 Ensembl Gene Model | MGI Sequence Detail 192170 C57BL/6J ±  kb
    transcript ENSMUST00000044608 Ensembl | MGI Sequence Detail 5019 Not Applicable  
    polypeptide ENSMUSP00000037774 Ensembl | MGI Sequence Detail 1234 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 1
      cDNA 26
      Primer pair 8
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-28107, MGI:2139495, MGI:2145204, MGI:2145380, MGI:2145512
    References
    more
    • Summaries
      All 125
      Developmental Gene Expression 39
      Gene Ontology 19
      Phenotypes 51
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory