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Ddr2 Gene Detail
Summary
  • Symbol
    Ddr2
  • Name
    discoidin domain receptor family, member 2
  • Synonyms
    Ntrkr3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345277
    NCBI Gene: 18214
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:169799876-169938331 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 76.84 cM, cytoband H1-H5
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4158 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345277
 protein coding gene Chr1:169799874-169938525 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016724
 protein coding gene Chr1:175661958-175803577 (-)
A/J MGP_AJ_G0016704
 protein coding gene Chr1:168476121-168615161 (-)
AKR/J MGP_AKRJ_G0016670
 protein coding gene Chr1:173554915-173700538 (-)
BALB/cJ MGP_BALBcJ_G0016665
 protein coding gene Chr1:168971761-169112461 (-)
C3H/HeJ MGP_C3HHeJ_G0016489
 protein coding gene Chr1:173806071-173947119 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017126
 protein coding gene Chr1:181474157-181627258 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014835
 protein coding gene Chr1:160243238-160373622 (-)
CAST/EiJ MGP_CASTEiJ_G0016069
 protein coding gene Chr1:173427659-173574107 (-)
CBA/J MGP_CBAJ_G0016464
 protein coding gene Chr1:187929658-188080209 (-)
DBA/2J MGP_DBA2J_G0016570
 protein coding gene Chr1:167351710-167492341 (-)
FVB/NJ MGP_FVBNJ_G0016568
 protein coding gene Chr1:165727343-165860648 (-)
LP/J MGP_LPJ_G0016641
 protein coding gene Chr1:176719261-176859904 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016593
 protein coding gene Chr1:195269529-195424308 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017163
 protein coding gene Chr1:173442097-173587558 (-)
PWK/PhJ MGP_PWKPhJ_G0015855
 protein coding gene Chr1:166580133-166723322 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015641
 protein coding gene Chr1:172205828-172345444 (-)
WSB/EiJ MGP_WSBEiJ_G0016131
 protein coding gene Chr1:173557184-173706391 (-)



Homology
more
  • Human Ortholog
    DDR2, discoidin domain receptor tyrosine kinase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDR2, discoidin domain receptor tyrosine kinase 2
  • Synonyms
    MIG20a, NTRKR3, TKT, TYRO10, WRCN
  • Links
    NCBI Gene ID: 4921
    neXtProt AC: NX_Q16832
    UniProt: Q16832

  • Chr Location
    1q23.3; chr1:162630863-162787405 (+)  GRCh38
Human Diseases
more
  • Diseases
    7 with human DDR2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    53 phenotypes from 6 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show dwarfism, reduced chondrocyte proliferation, shortened long bones and snout, and skull anomalies. Homozygotes for another null allele show similar skeletal defects, small hearts, short cardiomyocytes, lower cardiac collagen density, and altered cardiac function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    995
  • Tissues
    177
  • cDNA Data
    81
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026674 Ensembl Gene Model | MGI Sequence Detail 138456 C57BL/6J ±  kb
    transcript ENSMUST00000027985 Ensembl | MGI Sequence Detail 2928 Not Applicable  
    polypeptide ENSMUSP00000027985 Ensembl | MGI Sequence Detail 854 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000001446 discoidin domain-containing receptor 2
      (term hierarchy)
    • EC
      2.7.10.1
    • InterPro Domains
      IPR000421 Coagulation factor 5/8 C-terminal domain
      IPR048525 Discoidin domain-containing receptor 1/2, DS-like domain
      IPR008979 Galactose-binding-like domain superfamily
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050122 Receptor Tyrosine Kinase
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
    • GlyGen
      Q62371 5 sites
    Molecular
    Reagents
    less
    • All nucleic 82
      cDNA 81
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-19589, MGI:102686, MGI:2138594
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 21
      Gene Ontology 10
      Phenotypes 32
    • Earliest
      J:18515 Lai C, et al., An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. Neuron. 1991 May;6(5):691-704
    • Latest
      J:345901 Akinjiyan FA, et al., DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression. Oncogene. 2024 Jan;43(3):189-201
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory