Supt6 MGI Mouse Gene Detail - MGI:107726 - SPT6, histone chaperone and transcription elongation factor

Symbol

Supt6
Name

SPT6, histone chaperone and transcription elongation factor
Synonyms

5131400N11Rik, mKIAA0162, SPT6, Supt6h

Feature Type

protein coding gene
IDs

MGI:107726
NCBI Gene: 20926
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:78097575-78136798 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.74 cM
Mapping Data

9 experiments

SNPs within 2kb

776 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107726	protein coding gene	Chr11:78097572-78136813 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018770	protein coding gene	Chr11:79191454-79231807 (-)
A/J	MGP_AJ_G0018736	protein coding gene	Chr11:76167099-76207735 (-)
AKR/J	MGP_AKRJ_G0018706	protein coding gene	Chr11:78470505-78512292 (-)
BALB/cJ	MGP_BALBcJ_G0018710	protein coding gene	Chr11:76574591-76614009 (-)
C3H/HeJ	MGP_C3HHeJ_G0018523	protein coding gene	Chr11:78512588-78552483 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019161	protein coding gene	Chr11:81665207-81706199 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016796	protein coding gene	Chr11:73140578-73180429 (-)
CAST/EiJ	MGP_CASTEiJ_G0018077	protein coding gene	Chr11:78950820-78994161 (-)
CBA/J	MGP_CBAJ_G0018493	protein coding gene	Chr11:85227592-85275909 (-)
DBA/2J	MGP_DBA2J_G0018602	protein coding gene	Chr11:75747786-75787035 (-)
FVB/NJ	MGP_FVBNJ_G0018592	protein coding gene	Chr11:75336192-75375256 (-)
LP/J	MGP_LPJ_G0018673	protein coding gene	Chr11:79728887-79772357 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018618	protein coding gene	Chr11:85646516-85686137 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019201	protein coding gene	Chr11:78714388-78755056 (-)
PWK/PhJ	MGP_PWKPhJ_G0017848	protein coding gene	Chr11:76532916-76572805 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017639	protein coding gene	Chr11:78327420-78365858 (-)
WSB/EiJ	MGP_WSBEiJ_G0018130	protein coding gene	Chr11:78529983-78568484 (-)

Human Ortholog

SUPT6H, SPT6 homolog, histone chaperone and transcription elongation factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SUPT6H, SPT6 homolog, histone chaperone and transcription elongation factor
Synonyms

emb-5, SPT6, SPT6H
Links

HGNC:11470

NCBI Gene ID: 6830

neXtProt AC: NX_Q7KZ85

UniProt: Q7KZ85
Chr Location

17q11.2; chr17:28662198-28702679 (+) GRCh38

MGI Vertebrate Homology

Supt6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SUPT6H
Protein SuperFamily

Spt6
Gene Tree

Supt6

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Chemically induced (other)

1
Gene trapped

23
Targeted

3
Genomic Mutations

2 involving Supt6
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

68 strains or lines available

Mice homozygous for a knock-out allele exhibit lethality during pre-implantation development.

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All GO Annotations

28
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

799
Tissues

66
cDNA Data

13
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase supt6h

ZFIN supt6h

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All Sequences

42
RefSeq

5
UniProt

3
CCDS

CCDS25095.1

Ensembl

ENSMUSG00000002052 (Evidence)
NCBI Gene

20926

			Length	Strain/Species	Flank
genomic	20926	NCBI Gene Model \| MGI Sequence Detail	39224	C57BL/6J	± kb
transcript	NM_009297	RefSeq \| MGI Sequence Detail	6201	ZRU/MplStud
polypeptide	Q62383	UniProt \| EBI \| MGI Sequence Detail	1726	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015837 transcription elongation factor SPT6

(term hierarchy)
InterPro Domains

IPR028088 Helix-turn-helix DNA-binding domain of Spt6

IPR041692 HHH domain 9

IPR012340 Nucleic acid-binding, OB-fold

IPR012337 Ribonuclease H-like superfamily

IPR010994 RuvA domain 2-like

IPR003029 S1 domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR028083 Spt6 acidic, N-terminal domain

IPR042066 Spt6, Death-like domain

IPR035420 Spt6, SH2 domain

IPR035018 Spt6, SH2 domain, C terminus

IPR035019 Spt6, SH2 domain, N terminus

IPR023323 Tex-like domain superfamily

IPR023319 Tex-like protein, HTH domain superfamily

IPR017072 Transcription elongation factor Spt6

IPR032706 Transcription elongation factor Spt6, helix-hairpin-helix motif

IPR028231 Transcription elongation factor Spt6, YqgF domain

IPR006641 YqgF/RNase H-like domain

IPR037027 YqgF/RNase H-like domain superfamily
GlyGen

Q62383 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)

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All nucleic 23

Genomic 2

cDNA 16

Primer pair 4

Other 1

Microarray probesets 3

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MGD-MRK-36302, MGI:1922980, MGI:2144073

Summaries

All 58

Developmental Gene Expression 7

Gene Ontology 13

Phenotypes 15
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:309442 Mayere C, et al., Single-cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determination. FASEB J. 2021 Apr;35(4):e21452

TSS for Supt6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109386	Chr11:78136994-78137077 (-)	-238 bp
Tssr109385	Chr11:78136768-78136803 (-)	12 bp
Tssr109384	Chr11:78136500-78136542 (-)	277 bp
Tssr109383	Chr11:78124407-78124425 (-)	12,382 bp
Tssr109382	Chr11:78122890-78122905 (-)	13,900 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24