Vps72 MGI Mouse Gene Detail - MGI:1202305 - vacuolar protein sorting 72

Symbol

Vps72
Name

vacuolar protein sorting 72
Synonyms

Tcfl1, YL-1

Feature Type

protein coding gene
IDs

MGI:1202305
NCBI Gene: 21427
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr3:95018353-95030362 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.74 cM, cytoband F2
Mapping Data

2 experiments

SNPs within 2kb

356 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1202305	protein coding gene	Chr3:95018333-95030362 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027567	protein coding gene	Chr3:95803198-95816294 (+)
A/J	MGP_AJ_G0027526	protein coding gene	Chr3:92849141-92861272 (+)
AKR/J	MGP_AKRJ_G0027493	protein coding gene	Chr3:94988968-95002496 (+)
BALB/cJ	MGP_BALBcJ_G0027538	protein coding gene	Chr3:92619501-92631545 (+)
C3H/HeJ	MGP_C3HHeJ_G0027271	protein coding gene	Chr3:95272013-95284509 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027986	protein coding gene	Chr3:99370196-99383320 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025326	protein coding gene	Chr3:89209471-89223111 (+)
CAST/EiJ	MGP_CASTEiJ_G0026721	protein coding gene	Chr3:94557119-94571403 (+)
CBA/J	MGP_CBAJ_G0027248	protein coding gene	Chr3:102974561-102989379 (+)
DBA/2J	MGP_DBA2J_G0027387	protein coding gene	Chr3:92140806-92154144 (+)
FVB/NJ	MGP_FVBNJ_G0027358	protein coding gene	Chr3:90211774-90223341 (+)
LP/J	MGP_LPJ_G0027496	protein coding gene	Chr3:97093125-97106900 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027385	protein coding gene	Chr3:109100067-109113526 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028040	protein coding gene	Chr3:94644081-94658318 (+)
PWK/PhJ	MGP_PWKPhJ_G0026449	protein coding gene	Chr3:92019594-92031185 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026270	protein coding gene	Chr3:92939930-92953185 (+)
WSB/EiJ	MGP_WSBEiJ_G0026803	protein coding gene	Chr3:95030987-95044286 (+)

Human Ortholog

VPS72, vacuolar protein sorting 72 homolog

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VPS72, vacuolar protein sorting 72 homolog
Synonyms

CFL1, Swc2, TCFL1, YL-1, YL1
Links

HGNC:11644

NCBI Gene ID: 6944

neXtProt AC: NX_Q15906

UniProt: Q15906
Chr Location

1q21.3; chr1:151176304-151195321 (-) GRCh38

MGI Vertebrate Homology

Vps72 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: VPS72
Gene Tree

Vps72

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

22
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Vps72
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available

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All GO Annotations

27
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

797
Tissues

90
cDNA Data

82
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vps72

ZFIN vps72b

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All Sequences

40
RefSeq

2
UniProt

1
CCDS

CCDS38543.1

Ensembl

ENSMUSG00000008958 (Evidence)
NCBI Gene

21427

			Length	Strain/Species	Flank
genomic	21427	NCBI Gene Model \| MGI Sequence Detail	12010	C57BL/6J	± kb
transcript	NM_009336	RefSeq \| MGI Sequence Detail	1436	C57BL/6
polypeptide	Q62481	UniProt \| EBI \| MGI Sequence Detail	368	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017347 vacuolar protein sorting-associated protein 72

(term hierarchy)
InterPro Domains

IPR013272 Vps72/YL1, C-terminal

IPR008895 Vps72/YL1 family

IPR046757 Vps72/YL1, N-terminal

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All nucleic 82

cDNA 82

Microarray probesets 3

Summaries

All 55

Developmental Gene Expression 6

Diseases 1

Gene Ontology 12

Phenotypes 15
Earliest

J:24182 Horikawa I, et al., Molecular cloning of a novel human cDNA on chromosome 1q21 and its mouse homolog encoding a nuclear protein with DNA-binding ability. Biochem Biophys Res Commun. 1995 Mar 28;208(3):999-1007
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Vps72:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30489	Chr3:95018324-95018398 (+)	8 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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