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Zyx Gene Detail
Summary
  • Symbol
    Zyx
  • Name
    zyxin
  • Synonyms
    R75157
  • Feature Type
    protein coding gene
  • IDs
    MGI:103072
    NCBI Gene: 22793
  • Alliance
    gene page
  • Transcription Start Sites
    33 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:42326564-42337147 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 20.64 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    250 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103072
 protein coding gene Chr6:42326507-42337158 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030648
 protein coding gene Chr6:40866215-40876798 (+)
A/J MGP_AJ_G0030621
 protein coding gene Chr6:39079999-39090580 (+)
AKR/J MGP_AKRJ_G0030546
 protein coding gene Chr6:40342829-40353414 (+)
BALB/cJ MGP_BALBcJ_G0030631
 protein coding gene Chr6:39325438-39336009 (+)
C3H/HeJ MGP_C3HHeJ_G0030344
 protein coding gene Chr6:40377803-40388386 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031085
 protein coding gene Chr6:41889594-41900163 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028292
 protein coding gene Chr6:36961340-36972005 (+)
CAST/EiJ MGP_CASTEiJ_G0029748
 protein coding gene Chr6:40212029-40222514 (+)
CBA/J MGP_CBAJ_G0030320
 protein coding gene Chr6:43585831-43596414 (+)
DBA/2J MGP_DBA2J_G0030464
 protein coding gene Chr6:38929393-38939976 (+)
FVB/NJ MGP_FVBNJ_G0030420
 protein coding gene Chr6:38677313-38688234 (+)
LP/J MGP_LPJ_G0030552
 protein coding gene Chr6:40826091-40836666 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030454
 protein coding gene Chr6:45861336-45871907 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031115
 protein coding gene Chr6:40316632-40327213 (+)
PWK/PhJ MGP_PWKPhJ_G0029460
 protein coding gene Chr6:38492345-38503033 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029296
 protein coding gene Chr6:39878507-39889173 (+)
WSB/EiJ MGP_WSBEiJ_G0029824
 protein coding gene Chr6:40306372-40316950 (+)



Homology
more
  • Human Ortholog
    ZYX, zyxin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZYX, zyxin
  • Synonyms
    ESP-2, HED-2
  • Links
    NCBI Gene ID: 7791
    neXtProt AC: NX_Q15942
    UniProt: Q15942

  • Chr Location
    7q34; chr7:143381295-143391111 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice lacking functional copies of this gene are viable, fertile, and develop normally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    833
  • Tissues
    75
  • cDNA Data
    152
  • Literature Summary
    21
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029860 Ensembl Gene Model | MGI Sequence Detail 10584 C57BL/6J ±  kb
transcript ENSMUST00000203652 Ensembl | MGI Sequence Detail 2605 Not Applicable  
polypeptide ENSMUSP00000145451 Ensembl | MGI Sequence Detail 564 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 157
    Genomic 1
    cDNA 152
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-23936, MGI:2141796, MGI:2444302
References
more
  • Summaries
    All 70
    Developmental Gene Expression 21
    Gene Ontology 11
    Phenotypes 14
  • Earliest
    J:27710 Sadler I, et al., Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton. J Cell Biol. 1992 Dec;119(6):1573-87
  • Latest
    J:354517 Kliewe F, et al., Zyxin is important for the stability and function of podocytes, especially during mechanical stretch. Commun Biol. 2024 Apr 11;7(1):446
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory