Map2k2 MGI Mouse Gene Detail - MGI:1346867 - mitogen-activated protein kinase kinase 2

Symbol

Map2k2
Name

mitogen-activated protein kinase kinase 2
Synonyms

MAP kinase/Erk kinase, MEK2, Prkmk2

Feature Type

protein coding gene
IDs

MGI:1346867
NCBI Gene: 26396
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:80941749-80960531 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

5 experiments

SNPs within 2kb

409 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346867	protein coding gene	Chr10:80941749-80969809 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017536	protein coding gene	Chr10:81793141-81816680 (+)
A/J	MGP_AJ_G0017514	protein coding gene	Chr10:78901499-78921387 (+)
AKR/J	MGP_AKRJ_G0017475	protein coding gene	Chr10:81070472-81093696 (+)
BALB/cJ	MGP_BALBcJ_G0017476	protein coding gene	Chr10:79116700-79136753 (+)
C3H/HeJ	MGP_C3HHeJ_G0017299	protein coding gene	Chr10:81154574-81173258 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017930	protein coding gene	Chr10:84599281-84618390 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015619	protein coding gene	Chr10:75105136-75123458 (+)
CAST/EiJ	MGP_CASTEiJ_G0016866	protein coding gene	Chr10:81392597-81413053 (+)
CBA/J	MGP_CBAJ_G0017271	protein coding gene	Chr10:87895035-87920304 (+)
DBA/2J	MGP_DBA2J_G0017377	protein coding gene	Chr10:78095947-78114723 (+)
FVB/NJ	MGP_FVBNJ_G0017371	protein coding gene	Chr10:77339016-77360072 (+)
LP/J	MGP_LPJ_G0017448	protein coding gene	Chr10:82240323-82261401 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017397	protein coding gene	Chr10:89763162-89787563 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017971	protein coding gene	Chr10:81059479-81080600 (+)
PWK/PhJ	MGP_PWKPhJ_G0016647	protein coding gene	Chr10:78000265-78019319 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016437	protein coding gene	Chr10:80017782-80036936 (+)
WSB/EiJ	MGP_WSBEiJ_G0016926	protein coding gene	Chr10:81098000-81117412 (+)

Human Ortholog

MAP2K2, mitogen-activated protein kinase kinase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP2K2, mitogen-activated protein kinase kinase 2
Synonyms

CFC4, MAPKK2, MEK2, MKK2, PRKMK2
Links

HGNC:6842

NCBI Gene ID: 5605

neXtProt AC: NX_P36507

UniProt: P36507
Chr Location

19p13.3; chr19:4090321-4124122 (-) GRCh38

MGI Vertebrate Homology

Map2k2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MAP2K2
Gene Tree

Map2k2

Diseases

2 with human MAP2K2 associations

				Human Disease	Mouse Models
				cardiofaciocutaneous syndrome 4 IDs cardiofaciocutaneous syndrome 4 DOID:0111463 OMIM:615280
				small intestine adenocarcinoma IDs small intestine adenocarcinoma DOID:4906 NCI:C7888 UMLS_CUI:C0278803

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
35 phenotypes from multigenic genotypes
58 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

12
Targeted

6
Genomic Mutations

2 involving Map2k2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation are viable, fertile, and apparently normal.

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All GO Annotations

81
GO References

23

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

956
Tissues

203
cDNA Data

191
Literature Summary

34

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN map2k2a

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All Sequences

99
RefSeq

12
UniProt

9
CCDS

CCDS24044.1, CCDS83734.1

Ensembl

ENSMUSG00000035027 (Evidence)
NCBI Gene

26396

			Length	Strain/Species	Flank
genomic	26396	NCBI Gene Model \| MGI Sequence Detail	18783	C57BL/6J	± kb
transcript	NM_001428901	RefSeq \| MGI Sequence Detail	2485	C57BL/6
polypeptide	Q63932	UniProt \| EBI \| MGI Sequence Detail	401	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000010126 dual specificity mitogen-activated protein kinase kinase 2

(term hierarchy)
PDB

1JKY
EC

2.7.12.2
InterPro Domains

IPR050915 MAP kinase kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 197

cDNA 193

Primer pair 3

Other 1

Microarray probesets 3

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MGD-MRK-18661, MGI:101840, MGI:2143493

Summaries

All 166

Developmental Gene Expression 34

Gene Ontology 23

Phenotypes 58
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:354182 Sun M, et al., ERK signaling expands mammalian cortical radial glial cells and extends the neurogenic period. Proc Natl Acad Sci U S A. 2024 Mar 26;121(13):e2314802121

TSS for Map2k2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94671	Chr10:80941752-80941766 (+)	10 bp
Tssr94672	Chr10:80941767-80941838 (+)	54 bp
Tssr94673	Chr10:80953958-80953993 (+)	12,227 bp
Tssr94674	Chr10:80956767-80956820 (+)	15,045 bp
Tssr94675	Chr10:80959652-80959659 (+)	17,907 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24