Rab34 MGI Mouse Gene Detail - MGI:104606 - RAB34, member RAS oncogene family

Symbol

Rab34
Name

RAB34, member RAS oncogene family
Synonyms

Narr, Rah1

Feature Type

protein coding gene
IDs

MGI:104606
NCBI Gene: 19376
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:78079256-78083019 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.74 cM
Mapping Data

3 experiments

SNPs within 2kb

125 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104606	protein coding gene	Chr11:78079253-78083019 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018768	protein coding gene	Chr11:79170047-79173800 (+)
A/J	MGP_AJ_G0018734	protein coding gene	Chr11:76148063-76151808 (+)
AKR/J	MGP_AKRJ_G0018704	protein coding gene	Chr11:78452294-78456343 (+)
BALB/cJ	MGP_BALBcJ_G0018708	protein coding gene	Chr11:76556434-76560194 (+)
C3H/HeJ	MGP_C3HHeJ_G0018521	protein coding gene	Chr11:78493413-78497198 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019159	protein coding gene	Chr11:81641660-81646345 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016794	protein coding gene	Chr11:73121321-73125054 (+)
CAST/EiJ	MGP_CASTEiJ_G0018075	protein coding gene	Chr11:78930737-78934977 (+)
CBA/J	MGP_CBAJ_G0018491	protein coding gene	Chr11:85206565-85211330 (+)
DBA/2J	MGP_DBA2J_G0018600	protein coding gene	Chr11:75729365-75733120 (+)
FVB/NJ	MGP_FVBNJ_G0018590	protein coding gene	Chr11:75317296-75321013 (+)
LP/J	MGP_LPJ_G0018671	protein coding gene	Chr11:79707645-79713329 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018616	protein coding gene	Chr11:85625738-85629518 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019199	protein coding gene	Chr11:78695829-78699577 (+)
PWK/PhJ	MGP_PWKPhJ_G0017846	protein coding gene	Chr11:76511991-76516322 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017637	protein coding gene	Chr11:78303553-78309110 (+)
WSB/EiJ	MGP_WSBEiJ_G0018128	protein coding gene	Chr11:78509004-78512759 (+)

Human Ortholog

RAB34, RAB34, member RAS oncogene family

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAB34, RAB34, member RAS oncogene family
Synonyms

NARR, OFD20, RAB39, RAH
Links

HGNC:16519

NCBI Gene ID: 83871

neXtProt AC: NX_P0DI83, NX_Q9BZG1

UniProt: Q9BZG1
Chr Location

17q11.2; chr17:28714281-28718429 (-) GRCh38

MGI Vertebrate Homology

Rab34 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RAB34
Gene Tree

Rab34

Diseases

1 with human RAB34 associations

				Human Disease	Mouse Models
				orofaciodigital syndrome XX IDs orofaciodigital syndrome XX DOID:0060962 OMIM:620718

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Gene trapped

6
Targeted

6
Genomic Mutations

2 involving Rab34
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

49
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

38
cDNA Data

98
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rab34

ZFIN rab34a

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All Sequences

75
RefSeq

4
UniProt

6
CCDS

CCDS25094.1

Ensembl

ENSMUSG00000002059 (Evidence)
NCBI Gene

19376

			Length	Strain/Species	Flank
genomic	ENSMUSG00000002059	Ensembl Gene Model \| MGI Sequence Detail	3764	C57BL/6J	± kb
transcript	ENSMUST00000150941	Ensembl \| MGI Sequence Detail	795	Not Applicable
polypeptide	ENSMUSP00000123033	Ensembl \| MGI Sequence Detail	265	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000013610 Ras-related protein Rab-34

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR050227 Ras-related protein Rab

IPR001806 Small GTPase

IPR005225 Small GTP-binding protein domain

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All nucleic 103

Genomic 3

cDNA 99

Primer pair 1

Microarray probesets 5

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MGD-MRK-26043, MGI:2144135

Summaries

All 60

Developmental Gene Expression 4

Gene Ontology 12

Phenotypes 20
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:350463 Yamaguchi H, et al., Ciliary and non-ciliary functions of Rab34 during craniofacial bone development. Biochem Biophys Res Commun. 2024 Sep 10;724:150174

TSS for Rab34:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103237	Chr11:78079248-78079273 (+)	5 bp
Tssr103238	Chr11:78079278-78079309 (+)	38 bp
Tssr103239	Chr11:78079563-78079613 (+)	332 bp
Tssr103240	Chr11:78079632-78079661 (+)	391 bp
Tssr103241	Chr11:78079905-78079927 (+)	660 bp
Tssr103242	Chr11:78079937-78079952 (+)	689 bp
Tssr103243	Chr11:78080422-78080434 (+)	1,172 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24